2016
DOI: 10.1007/s00467-016-3424-3
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Desensitization protocols for prospective pediatric renal transplant recipients

Abstract: Desensitization protocols should be considered for children with positive crossmatches awaiting renal transplantation. Children are sensitized usually due to previous renal (and/or other solid-organ) transplants but can be from administration of blood and/or platelet transfusions, infections, and immunizations (as sensitization from pregnancy is a rare occurrence in pediatric patients). However, the definition of HLA-incompatible (HLAi) renal transplantation in the literature varies and is best considered only… Show more

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Cited by 6 publications
(1 citation statement)
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“…Direct HLA incompatible (HLAi) or ABO incompatible (ABOi) transplantation may be offered to highly sensitised patients or those with an ABO-incompatible living donor. 13 , 14 This involves removing anti-blood group antibodies and/or HLA antibodies from the recipient, prior to transplantation—effectively “desensitizing” the patient to allow safe transplantation to take place. Typically, this is feasible only in patients with lower titres of anti-donor antibodies.…”
Section: Introductionmentioning
confidence: 99%
“…Direct HLA incompatible (HLAi) or ABO incompatible (ABOi) transplantation may be offered to highly sensitised patients or those with an ABO-incompatible living donor. 13 , 14 This involves removing anti-blood group antibodies and/or HLA antibodies from the recipient, prior to transplantation—effectively “desensitizing” the patient to allow safe transplantation to take place. Typically, this is feasible only in patients with lower titres of anti-donor antibodies.…”
Section: Introductionmentioning
confidence: 99%