Desensitization to carboplatin in low‐grade glioma. A revision of 100 treatments in children

Desensitization in children allergic to drugs: Indications, protocols, and limits

“…Vaccines, chemotherapeutic agents, mAbs, analgesics, and radiocontrast media may also be associated with DHR in children. 39 The experience of the authors is mainly in the field of DDS to antibiotics 28 and chemotherapy for solid tumors 26 in young children, although the experience in leukemias and lymphomas has been growing over recent years.…”

“…DDS can be performed at any age 28,29 . A revision of 100 treatments in children shows the experience of the authors in desensitizing children with HSR to carboplatin 26 …”

“…This information, together with the allergological work‐up, may allow to suspect the underlying mechanism and to design the DDS strategy accordingly (Table 1). 26 …”

“…We have experienced more frequent and recalcitrant symptoms, which often recur even after adaptations to subsequent protocols and the inclusion of premedication. Although we do not experience more severe reactions, the management of these breakthrough symptoms has been specially challenging 26 …”

“…An example of such adaptations is shown in Figure 3B,C. An intermediate step before the one at which symptoms arise can be introduced, as well as another fourth, final more diluted bag can be considered 6,26 . Premedication reinforcement may be applied.…”