Desenvolvimento da marcação da doxorrubicina com Tc-99m: estudos in vitro e in vivo

Use of99mTc-doxorubicin scintigraphy in females with breast cancer: a pilot study

“…Based on a previous experience, 24 doxorubicin was labelled with 99m Tc. Briefly, doxorubicin was incubated for 10 min with a reducing agent, and then 370 MBq (10 mCi) of 99m Tc was added.…”

“…[16][17][18] We have also used 99m Tc-doxorubicin in dogs and cats in order to evaluate its uptake in different kinds of tumours, with promising results, which led to the approval of this pilot trial. 24 …”