Desenvolvimento de uma formulação semissólida à base de epiisopiloturina e avaliação da sua estabilidade

Carneiro, Eduardo de Carvalho; Neto, Alcides Barroso de Souza; Sousa, Eliciane Maria Linhares; Júnior, José Rodrigues dos Santos; Pereira, Higinalice da Silva; Feitoza, Ysla Pontes; Véras, Leiz Maria Costa

doi:10.33448/rsd-v12i3.40551

Cited by 5 publications

(4 citation statements)

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“…Ethmoidal arteries, which originate in the ophthalmic and internal carotid arteries, provide an abundant blood supply to the nose [8]. Substances can enter the central nervous system via the perivascular areas surrounding these arteries [5,11].Studies comparing intranasal and arterial administration in animals have shown that substances administered in the former route enter the cerebral perivascular spaces within 20 minutes [16], are found in greater concentrations in the dura mater and circle of Willis [17], and are found in greater concentrations in the deep and superficial cervical nodes of rats [95], indicating that they may be transported via lymphatic drainage from the nasal passages and CSF. The maxillary, ophthalmic, and facial arteries, all of which are branches of the carotid artery, are the primary routes through which intranasal medicines reach the central nervous system.…”

Section: Intranasal Administration As An Alternative To the Oral Rout...mentioning

confidence: 99%

“…More research into SEDDS technology [14] has been prompted by the commercialization of drugs like SandimmunNeoral®, (cyclosporin A) by Novartis Pharmaceuticals (USA), Norvir® by AbbVie Inc. (North Chicago, IL, USA), and Fortovase® by Roche (Basel, Switzerland). [15,16] In addition to these, there are currently on the market products that are based on liquid SEDDS that are either encapsulated in hard gelatin capsules (Gengraf® (cyclosporine) (AbbVie Inc., North Chicago, IL, USA) or in soft gelatin capsules (Agenerase® (amprenavir) (Glaxo Group, United Kingdom), Depakene® (valproic acid) (AbbVie Inc., North Chicago, [17,18]. It's true that SEDDS might be expanded to include most medications from BCS's classes II and IV.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advancement in Self Emulsifing Drug Delivery System

Bist

Faruk

2023

J. Res. Appl. Sci. Biotechnol.

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Every day, researchers make new attempts to identify neurotherapeutics, but few of them make it to clinical trials. The main cause is their low bioavailability, which is connected to low water solubility, low permeability through biological membranes, and the hepatic first-pass metabolism. However, the most significant challenge in administering drugs to the brain is overcoming the blood-brain barrier. In order to get around it, intranasal administration has become more popular, sometimes even more so than oral administration. Because of its structure, the nasal cavity can bypass the blood-brain barrier and transport drugs to the brain directly. Nasal absorption increases the systemic bioavailability of highly processed substances because they bypass the hepatic first-pass metabolism. However, due to their unique physicochemical properties, most neurotherapeutics must be synthesized in lipidic nanosystems as self-emulsifying drug delivery systems (SEDDS). To load large quantities of lipophilic medicines into micro or nanoemulsions, these isotropic mixes of oils, surfactants, and co-surfactants are diluted in water. The goal of SEDDS is to increase the stability of labile pharmaceuticals against enzymatic activity, boost drug penetration through absorptive membranes, and reduce the likelihood of drug precipitation at absorption sites. Therefore, improved brain targeting and bioavailability of medications might be anticipated by combining the benefits of SEDDS with those of the intranasal route for brain delivery. In order to better understand the mechanisms involved in the intranasal administration of pharmaceuticals loaded in SEDDS, this paper provides a comprehensive characterization of SEDDS as a lipidic nanosystem. Finally, the in vivo effects of intranasal or oral delivery of SEDDS, showing their superiority over standard solutions or suspensions, are described.

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Section: Intranasal Administration As An Alternative To the Oral Rout...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advancement in Self Emulsifing Drug Delivery System

Bist

Faruk

2023

J. Res. Appl. Sci. Biotechnol.

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“…Ademais, os valores de pH das formulações oscilaram em torno de 5,0 a 5,5, visto que, essa variação ocorreu formulação 2, em seu 2° ciclo de estresse térmico, possivelmente por reações químicas como hidrólise, impurezas, decomposição e/ou armazenamento inadequado [21]. Em síntese, os aspectos faciais são subdivididos em camadas, onde no estrato córneo apresenta um pH de 5,5, sendo ele, o primeiro a ser exposto a contato com produtos cosméticos.…”

Section: Determinação De Ph E Densidadeunclassified

Synthesis and Evaluation of the Preliminary Stability of White Clays Containing Açaí (Euterpe oleracea) and Acerola (Malpighia emarginata) Powder for Topical use

Costa,

Maia,

Pinheiro

et al. 2023

IJAERS

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Clays are used in cosmetology because they have moisturizing, rejuvenating and antioxidant properties. Such characteristics are enhanced with the combination of actives, such as açaí powder, rich in antioxidant activities, and acerola powder, which has B complex vitamins, but its highest concentration is vitamin C, thus, the two actives minimize damage against free radicals, promoting an improvement in the appearance of the skin. The formulations were developed at three different concentrations, where they were stored in polyethylene pots and underwent preliminary stability tests, where they were subjected to six cycles of thermal stress, since, at the end of each cycle, control parameters were analyzed quality, such as organoleptic characteristics, such as color, odor and appearance, to assess instabilities in formulations. Thus, pH and density values were also determined. In addition, during the ice-thaw process, the samples remained unchanged in terms of initial color, however, the aspects showed evidence of instability, that is, they showed slight changes, that is, the movements of the dispersed active particles to the edges of the pots. In addition, the pH values ranged from 5.0 to 5.5, since it is the appropriate pH value for the skin, as it resembles the stratum corneum, which has a pH of 5.5. In the same follow-up, the results referring to density, showed a high coefficient of variation, but during the statistical analyses, the formulations remained stable, that is, they are suitable for the next test steps.

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“…Sendo assim, realizar o teste de pH é relevante e necessário para assegurar a estabilidade e eficácia de uma formulação. O pH do gel se manteve aceitável de acordo com a faixa indicada, sendo um fator importante para os testes da formulação analisada, pois pH baixo pode causar irritação, sensibilidade e alergia, entre outros fatores (Souza, 2020;Carneiro et al, 2023;Cavalcante et al, 2022).…”

Section: Determinação Do Phunclassified

Síntese e estudo de estabilidade preliminar de géis de natrosol contendo extrato de Hamamelis virginiana

Pinheiro,

Maia,

Costa

et al. 2023

RSD

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O extrato de hamamélis é um excelente antiinflamatório por apresentar ação vasodilatadora, utilizado pela indústria farmacêutica na forma de gel antivaricoso. O objetivo deste estudo é avaliar a estabilidade térmica de cinco formulações de géis de Natrosol® contendo extrato de hamamélis. Durante o ensaio de estabilidade preliminar, os géis foram submetidos a 6 ciclos de estresse térmico, utilizando as temperaturas de 45±2°C e 5±2°C, respectivamente, durante 24 cada uma, o equivalente a 1 ciclo. Ao final de cada ciclo gelo-degelo, analisou-se em cada formulação através de caracterização organoléptica (cor, odor e aspecto), pH e densidade, e aplicou-se análise estatísticas dos dados obtidos. A formulação 2, apresentou em determinados momentos, turbidez em sua coloração, indicando inviabilidade da amostra, diferindo no entanto, do restante das formulações, que apresentaram caráter positivo, preservando sua estabilidade ao longo das análises, desempenhando conformidade com os guias de estabilidade. Desse modo, F1, F3, F4 e F5, demonstram viabilidade em seguir para as próximas etapas de estabilidade de longa duração.

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Desenvolvimento de uma formulação semissólida à base de epiisopiloturina e avaliação da sua estabilidade

Cited by 5 publications

References 0 publications

Recent Advancement in Self Emulsifing Drug Delivery System

Recent Advancement in Self Emulsifing Drug Delivery System

Synthesis and Evaluation of the Preliminary Stability of White Clays Containing Açaí (Euterpe oleracea) and Acerola (Malpighia emarginata) Powder for Topical use

Síntese e estudo de estabilidade preliminar de géis de natrosol contendo extrato de Hamamelis virginiana

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