Desequilibrio de aminoácidos plasmáticos en pacientes autistas y en sujetos con trastorno de déficit de atención con hiperactividad

Zavala, María Eugenia Manjarrez; Castejón, H V; Ortega, Priscila; Castejón, Orlando J.; I, Arroyo Hidalgo; Montiel, Néstor

doi:10.33588/rn.3305.2001093

Cited by 6 publications

(1 citation statement)

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“…The association of ASD and phenylketonuria (PKU), a disease induced by deficiency in the metabolism of phenylalanine, has been well-documented, and children with PKU often show some autistic-like behavior (74)(75)(76). Significant differences in urine and plasma levels of phenylalanine have also been found to be associated with ASD in several independent previously published studies (9,(77)(78)(79)(80)(81)(82), although some of these results were contradictory, all their data points to the perturbation of phenylalanine metabolism in ASD. Our results further confirmed this association, as perturbed phenylalanine metabolism in ASD was found in both of the metabolic pathway analysis results from the urine and plasma samples.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study

Cai

Meng

et al. 2021

Front. Psychiatry

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Background: Autism spectrum disorder (ASD) is defined as a pervasive developmental disorder which is caused by genetic and environmental risk factors. Besides the core behavioral symptoms, accumulated results indicate children with ASD also share some metabolic abnormalities.Objectives: To analyze the comprehensive metabolic profiles in both of the first-morning urine and plasma samples collected from the same cohort of autistic boys.Methods: In this study, 30 autistic boys and 30 tightly matched healthy control (HC) boys (age range: 2.4~6.7 years) were recruited. First-morning urine and plasma samples were collected and the liquid chromatography–mass spectrometry (LC-MS) was applied to obtain the untargeted metabolic profiles. The acquired data were processed by multivariate analysis and the screened metabolites were grouped by metabolic pathway.Results: Different discriminating metabolites were found in plasma and urine samples. Notably, taurine and catechol levels were decreased in urine but increased in plasma in the same cohort of ASD children. Enriched pathway analysis revealed that perturbations in taurine and hypotaurine metabolism, phenylalanine metabolism, and arginine and proline metabolism could be found in both of the plasma and urine samples.Conclusion: These preliminary results suggest that a series of common metabolic perturbations exist in children with ASD, and confirmed the importance to have a comprehensive analysis of the metabolites in different biological samples to reveal the full picture of the complex metabolic patterns associated with ASD. Further targeted analyses are needed to validate these results in a larger cohort.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study

Cai

Meng

et al. 2021

Front. Psychiatry

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Altered amino acid excretion in children with autism

Evans

Dunstan

Rothkirch

et al. 2008

Nutritional Neuroscience

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Autism is a complex and life-long behavioural disorder of unknown aetiology. Recent reports have indicated the involvement of digestive tract dysfunction and possible complications from inadequate nutrition. In this study, 34 autistic children (12 untreated and 22 receiving therapeutic treatments related to digestive function and nutritional uptake) and 29 control subjects (all 5-15 years of age) were investigated to determine whether there were any anomalies in the urinary excretion of amino acids, glucose, sucrose, arabinose and tartaric acid using GC/FID and GC/MS analysis techniques. Significantly lower relative urinary levels of essential amino acids were revealed for both the untreated (mean +/- SEM, 32.53 +/- 3.09%) and treated (31.98 +/- 2.87%) autistic children compared with the controls (37.87 +/- 1.50%). There were no significant differences in measured excretions of sugars or tartaric acid. It was concluded that the untreated autistic children had evidence of altered metabolic homeostasis.

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The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats

et al. 2020

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Under paradigms of combined intravenous cocaine and ethanol self-administration, the effects on behavior have been poorly explored. Numerous studies have found sex differences in amino acids profile and behavioral responses to each drug, yet few have focused on the interactions between cocaine and ethanol. The main objective of this work was to explore the acquisition and maintenance of intravenous self-administration behavior with a combination of cocaine and ethanol in male and female young adult rats. Likewise, the amino acids profile in blood plasma was quantified 48 hours after the last self-administration session. Male and female 52 days old Wistar rats were randomly assigned to one of 3 groups: i) saline control, ii) cocaine (1 mg/kg bodyweight/injection) and iii) cocaine and ethanol (1 mg + 133 mg/kg bodyweight/ injection). After 24 self-administration sessions carried out on a fixed-ratio-1 schedule, with a limit of 15 doses per session, 14 plasma amino acids were quantified by mean Capillary Electrophoresis technique. The curve of cocaine and ethanol combined self-administration was similar to that associated with cocaine administration alone, with females acquiring self-administration criterion before males. The self-administration of cocaine and ethanol altered the plasma concentration and relative ratios of the amino acid L-Tyrosine. In our intravenous self-administration model, females appeared more vulnerable to acquire abusive consumption of the cocaine and ethanol combination, which altered plasma L-Tyrosine levels.

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Desequilibrio de aminoácidos plasmáticos en pacientes autistas y en sujetos con trastorno de déficit de atención con hiperactividad

Cited by 6 publications

References 0 publications

Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study

Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study

Altered amino acid excretion in children with autism

The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats

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