Design a PEGylated nanocarrier containing lemongrass essential oil (LEO), a drug delivery system: Application as a cytotoxic agent against breast cancer cells

Rahimi, Ghasem; Yousefnia, Saghar; Angnes, Lúcio; Negahdary, Masoud

doi:10.1016/j.jddst.2023.104183

Cited by 8 publications

(3 citation statements)

References 58 publications

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“…Other studies, however, have drawn attention to LGEO’s toxicity, particularly with regard to cancer cells. Citral has been shown to have anti-cancer properties by causing apoptosis in breast cancer cells [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review

Kusuma,

Perdana,

Vágvölgyi

et al. 2024

Pharmaceuticals

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Lemongrass is a medicinal plant that produces essential oil with a variety of therapeutic properties. Although lemongrass essential oil (LGEO) is promising in clinical applications, the existing knowledge on the efficacy and safety of LGEO remains limited. This scoping review aimed to identify, summarize, and synthesize existing literature related to the clinical applications of LGEO to provide an overview of its potential therapeutic benefits for patients. Three databases (PubMed, Web of Science, Scopus) were used following the PRISMA-ScR guidelines to find articles published between 1 January 2013, and 1 November 2022. A total of 671 records were identified and 8 articles were included in this scoping review. The majority of patients received oromucosal and topical treatment. The results of the studies suggest that LGEO might be a useful tool in the treatment of periodontitis, gingivitis and oral malodour, with similar efficacy to chlorhexidine (anti-gingivitis effect) and doxycycline (periodontitis). Additionally, LGEO has the potential for treating pityriasis versicolor and preventing skin aging and may have anti-dandruff effects. These findings not only underscore the diverse clinical potential of LGEO but also emphasize its comparable efficacy to established treatments. Further research is imperative to comprehensively evaluate LGEO’s effectiveness, safety, mechanisms of action, potential interactions with other medications, and its long-term tolerability across diverse populations.

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Section: Discussionmentioning

confidence: 99%

Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review

Kusuma,

Perdana,

Vágvölgyi

et al. 2024

Pharmaceuticals

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“…Studies show that liposomes hold promise as effective carriers of EOs and EO compounds to enhance anticancer therapeutic efficiency (Sherry et al, 2013). For instance, a recent study found that liposomes containing C. citratus EO, prepared using soybean phosphatidylcholine and modified with PEG, exhibited increased apoptosis in three BC cell lines (MCF‐7, MDA‐MB‐231, and SKBR3) compared to the free EO (Rahimi et al, 2023). Likewise, O. vulgare EO‐loaded in phospholipon 90H liposomes demonstrated significantly higher cytotoxic activity against MCF‐7 cells than the free EO (Kryeziu et al, 2022).…”

Section: Nanoencapsulation Of Eos and Their Constituentsmentioning

confidence: 99%

Essential oils and their nanoformulations for breast cancer therapy

Thalappil,

Singh,

Carcereri de Prati

et al. 2023

Phytotherapy Research

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Breast Cancer (BC) is the most prevalent type of cancer in the world. Current treatments include surgery, radiation, and chemotherapy but often are associated with high toxicity to normal tissues, chemoresistance, and relapse. Thus, developing novel therapies which could combat these limitations is essential for effective treatment. In this context, phytochemicals are increasingly getting popular due to their safety profile, ability to efficiently target tumors, and circumvent limitations of existing treatments. Essential Oils (EOs) are mixtures of various phytochemicals which have shown potential anticancer activity in preclinical BC models. However, their clinical translation is limited by factors such as high volatility, low stability, and poor solubility. Nanotechnology has facilitated their encapsulation in a variety of nanostructures and proven to overcome these limitations. In this review, we have efficiently summarized the current knowledge on the anticancer effect of EOs and constituents in both in in vitro and in in vivo BC models. Further, we also provide a descriptive account on the potential of nanotechnology in enhancing the anti‐BC activity of EOs and their constituents. The papers discussed in this review were selected using the keywords “antiproliferative Essential Oils in breast cancer,” “anticancer activity of Essential Oil in breast cancer,” and “cytotoxicity of Essential Oils in breast cancer” performed in PubMed and ScienceDirect databases.

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“…C. citratus plant leaves and other parts are utilized in food, cosmetics, and pharmaceutical products [27,28]. One of the most significant therapeutic plants, lemongrass has several uses in conventional medicine [29,30]. Additionally, it can be used to treat HIV side effects, including secondary bacterial infections [1,31].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Bioactive Potential of Moroccan Lemongrass (Cymbopogon citratus): Investigations on molecular weight distribution, antioxidant and antimicrobial potentials

Tazi,

El moujahed,

Jaouad

et al. 2024

Preprint

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In the Lemongrass (Cymbopogon citratus), the investigations showed a wide range of active molecules their biological properties. However, most of these studies were conducted on the wid varieties, while cultivated plan addressed. This study aimed to characterize the biomolecules and biological activities of Lemongrass growing us African conditions sons in in Marocco. Marocco. Phenolic compound profiles of aqueous (AE) E) ethanol ethanol (EE), (EE), and methanol (ME) extract: fractions were obtained with steric exclusion chromatography on Sephadex 050 gel and identified by LC-MS/MS polyphenols (TPC), flavonoids (TFC), and antioxidant activities (FRAP: scavenging value and TAC: Total Antioxidant C the fraction were evaluated as well as the antimicrobial activity Obtained results showed that the ME contained e compounds (ie. Apigenine-7-0-rutinoside and myricitine-3-0-rutinoside). The AE showed the presence of five mole kaemiferol-3-0-glucuronide), while EE showed the presence of three molecules (Le. Quercetine-3-0-rutinoside). Reg chemical characterization, the rization, e highest value of Total phenolic content (TPC) was obtained in conten btained in AE ΑΕ (25) (4.60-0.29 mg highest value of Total flavonoids content (TFC) was obtained Ined in ME (29) (0.7±0.08 mg/g). Concerning the antioxide the highest FRAP was obtained in ME (29) (97.89%) and the highest total antioxidant capacity (TAC) was obtained (89.89%) Correlation between FRAP, TPC, and TFC was noted poly in fractions of AE and ME. All tested extracts of and their fractions showed a significant antimicrobial effect. The lowest minimum inhibitory concentration (MIC) wa for ME against E. col. Extracts biological activities and their fractions were governed by their active molecules. Ther new and clarify a novel aspect of bioactive molecules in the extracts of cultivated C. citratus Equaly, throughout this we clarified the relationship between identified molecules and their biological properties including antioxidant and comparative studies new activities, which is new for the study area. This study is suggested to be a reference. assays of other biological activities for the study plant

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Design a PEGylated nanocarrier containing lemongrass essential oil (LEO), a drug delivery system: Application as a cytotoxic agent against breast cancer cells

Cited by 8 publications

References 58 publications

Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review

Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review

Essential oils and their nanoformulations for breast cancer therapy

Exploring the Bioactive Potential of Moroccan Lemongrass (Cymbopogon citratus): Investigations on molecular weight distribution, antioxidant and antimicrobial potentials

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