Design, analysis and fabrication of solid polymer microneedle patch using CO2 laser and polymer molding

Anbazhagan, Gowthami; Suseela, Sreeja Balakrishnapillai; Sankararajan, Radha

doi:10.1007/s13346-023-01296-w

Cited by 19 publications

(10 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is an overall two-stage efficient process used to produce distinct geometries and dimensions of solid microneedle height less than 2.5 mm [218]. Anbazhagan et al used a CO2 laser and polymer molding technique to produce 10x10 designed microneedle array structure [219]. In this study has been revealed that the laser engraving method could directly create different geometries of microneedle molds by varying the laser scan speed and power.…”

Section: Laser Cuttingmentioning

confidence: 82%

“…In this study has been revealed that the laser engraving method could directly create different geometries of microneedle molds by varying the laser scan speed and power. Moreover, microneedles were manufactured by casting the PDMS on the acrylic mold (produced by CO2 laser) and these microneedles showed high mechanical strength for good skin penetration [219].…”

Section: Laser Cuttingmentioning

confidence: 99%

See 1 more Smart Citation

Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

View full text Add to dashboard Cite

The delivery of therapeutical molecules through the skin, particularly to its deeper layers is impaired due to the stratum corneum layer, which acts as barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consists on an array of microscale needles. This particular biomedical device had been drawing attention due to their ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size and composition. The design process of a microneedle device must take in account several factors, like the location delivery, the material and manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application, cosmetics, therapy, diagnosis, tissue engineering, sample extraction, cancer research, wound healing, among others.

show abstract

Section: Laser Cuttingmentioning

confidence: 82%

Section: Laser Cuttingmentioning

confidence: 99%

Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, one study found that a cone is the optimal shape of MNs for ovalbumin delivery in terms of skin insertion ratio [20], and the same shape was observed to have the optimal penetration depth in human skin [16]. Moreover, conical MNs were also observed to have better mechanical stability and penetration capabilities as compared to pyramidal MNs [22]. Uppuluri et al [23] studied the effect of MN height (600, 900, 1200, and 1500 µm) on the transdermal delivery of Zolmitriptan, and showed that increasing the needle height increased the drug permeation into pig ear skin.…”

Section: Introductionmentioning

confidence: 99%

A penetration efficiency model for the optimization of solid conical microneedles’ geometry

Piccolo,

Bornillo,

Micheli

et al. 2024

J. Micromech. Microeng.

View full text Add to dashboard Cite

Microneedles are promising alternatives to pills and traditional needles as drug delivery systems due to their fast, localized, and relatively less painful administration. Filling a knowledge gap, this study investigated and optimized the most influential geometrical factors determining the penetration efficiency of microneedles. The effects of height, base diameter, and tip diameter were analyzed using the finite element method, with results showing that the most influencing factor was base diameter, followed by height. Moreover, the taper angle, which is dependent on all the geometrical factors, was found to directly affect the penetration efficiency at a fixed height. An additional model was developed to relate the height and taper angle to penetration efficiency, and the results were experimentally validated by compression testing of microneedle array prototypes printed using two-photon photolithography. The numerical model closely predicted the experimental results, with a root mean square error of 9.35. The results of our study have the potential to aid the design of high-penetration efficiency microneedles for better functionality and applicability.

show abstract

“…Extensive research was conducted by various industries and academia to enhance the fabricated microneedle quality, and repeatability using AM processes [ 56 , 57 , 58 , 59 , 60 ]. Caudill et al demonstrated the AM technique as a rapid, complex, cost-effective, and large-volume manufacturing process to fabricate customized microneedle master molds.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Aldawood,

Parupelli,

Andar

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Microneedle (MN) technology is an optimal choice for the delivery of drugs via the transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine delivery, and disease diagnostics. The MN is a biomedical device that offers many advantages including but not limited to a painless experience, being time-effective, and real-time sensing. This research implements additive manufacturing (AM) technology to fabricate MN arrays for advanced therapeutic applications. Stereolithography (SLA) was used to fabricate six MN designs with three aspect ratios. The MN array included conical-shaped 100 needles (10 × 10 needle) in each array. The microneedles were characterized using optical and scanning electron microscopy to evaluate the dimensional accuracy. Further, mechanical and insertion tests were performed to analyze the mechanical strength and skin penetration capabilities of the polymeric MN. MNs with higher aspect ratios had higher deformation characteristics suitable for penetration to deeper levels beyond the stratum corneum. MNs with both 0.3 mm and 0.4 mm base diameters displayed consistent force–displacement behavior during a skin-equivalent penetration test. This research establishes guidelines for fabricating polymeric MN for high-accuracy and low-cost 3D printing.

show abstract

Design, analysis and fabrication of solid polymer microneedle patch using CO2 laser and polymer molding

Cited by 19 publications

References 58 publications

Microneedles Patch: Design, Fabrication and Applications

Microneedles Patch: Design, Fabrication and Applications

A penetration efficiency model for the optimization of solid conical microneedles’ geometry

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Contact Info

Product

Resources

About