This paper presents a fully symmetrical sense amplifier topology for advanced non-volatile memories. The proposed structure ensures zero systematic offset, together with adequate rejection of disturbs coming from capacitive coupling with noisy substrate, power supply, and ground. The presented topology has been designed for phase change memories, however, it is also suitable for use in other non-volatile storage devices such as magnetic RAMs and Flash memories. Experimental results on sensing time, offset, and sensitivity demonstrated the effectiveness of the proposed scheme.