A highly sensitive and simple structure side-polished micro-structured ber (MOF) refractive index (RI) sensor based on surface plasmon resonance (SPR) is proposed and studied by the nite element method (FEM). The gold nano lm used to stimulate plasmons is directly deposited on the inner wall of the open-loop channel of a MOF consisting of an arrangement of six cladding air-holes. The sample analyte is arranged on the outer surface of the optical ber to improve the utilization rate of the sensor and reduce the tediousness of operation. Meanwhile, in order to increase the leakage intensity of evanescent eld, three large air-holes were introduced near the ber core. Research has shown that the proposed sensor can achieve sensing detection in the range of 1.19-1.37 RI. The maximum sensitivity in the x-polarized direction can reach 12,500 nm/RIU, and its corresponding resolution is 3.64 × 10 − 5 RIU. Moreover, it has a high linear response of 0.9944 within the RI detection range of 1.19-1.33. Obviously, the proposed sensor has a simple structure, wide RI detection range, and high sensitivity, which can make it widely used in biomedical and analytical chemistry.