Design and antimicrobial activity of piperazine polymer nanocomposite

Jalageri, Manohara Dhulappa; Puttaiahgowda, Yashoda Malgar; Hariprasad,

doi:10.1016/j.matpr.2019.05.003

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…Inclusion of this moiety in the polymer backbone not only enhances the degradation rate but also imparts antimicrobial properties when quaternized. [28][29][30][31] Antimicrobial materials include quaternary phosphonium salts, ammonium salts, metal ions such as silver ions, antibacterials like ciprofloxacin, and so on. [32][33][34][35][36] Quaternary ammonium polymeric salts have the potential to enhance the efficiency of several existing low-molecular weight antibacterial agents while simultaneously lowering their residual toxicity.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial piperazine‐derived quaternized copolyesters with controlled degradability

Goel

Kaur

Singh

et al. 2023

J of Applied Polymer Sci

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The slow degradability of aliphatic polyesters can be attributed to their poor hydrophilicity. In this article, we report on a series of biodegradable and biocompatible pH-responsive piperazine-based copolyesters labeled P2-P7 synthesized by melt polycondensation approach that exhibit tunable hydrophilicity with antibacterial properties. X-ray diffraction analysis showed the copolymers to be highly crystalline, with their crystallinity in the range of 41%-55%. Contact angle measurements showed moderate hydrophilicity, with a water contact angle of 59 -71 for P2-P7 suggesting that the incorporation of piperazine units in the copolymer backbone moderately improves their hydrophilicity.N-alkylation with methyl iodide further enhanced their hydrophilicity with their measured contact angles changing from 62 in unalkylated P2 to 27 in the fully alkylated analogue P12. The effect of crystallinity and hydrophilicity on polyester degradation was systematically investigated by hydrolytic degradation studies. The quaternized copolymer P10 showed $39% reduction in molecular weight, whereas only $19% of P2 was degraded in 8 weeks, thus exhibiting faster degradation in the quaternized polyester. The biocompatibility with U2OS cells and the antibacterial properties established their importance as potential biomedical materials.

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Section: Introductionmentioning

confidence: 99%

Antibacterial piperazine‐derived quaternized copolyesters with controlled degradability

Goel

Kaur

Singh

et al. 2023

J of Applied Polymer Sci

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“…Piperazine, a six-membered heterocyclic ring with two opposing nitrogen atoms, provides a large polar surface area, structural rigidity, and hydrogen-bond acceptors and donors, which oen lead to enhanced target affinity, specicity, water solubility, oral bioavailability, and ADME (i.e., absorption, distribution, metabolism, and excretion) properties. 2,[77][78][79][80][81][82] The absence of vinyl groups and multifunctional groups in the piperazine molecule restricts their use in the synthesis of polymers though piperazine and substituted piperazine derivatives are extensively used as antibiotic, anticancer, antimicrobial, antipsychotic, antidepressant drugs and so forth.…”

Section: Introductionmentioning

confidence: 99%

Piperazine based antimicrobial polymers: a review

2021

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“…Numerous technologies for AMCs are reported in literature: (1) AMCs possess active eluting agents such as antibiotics, nanoparticles or ions; (2) the contact active immobilized molecules such as chitosan/quaternary ammonium polymers or peptides; (3) light‐activated molecules such as TiO 2 or photosensitizers 13,28–33 . The major strategies considered for developing antimicrobial surfaces are (i) antibacterial agent release (ii) contact‐killing and (iii) anti‐adhesion 34 .…”

Section: Introductionmentioning

confidence: 99%

“…(3) light-activated molecules such as TiO 2 or photosensitizers. 13,[28][29][30][31][32][33] The major strategies considered for developing antimicrobial surfaces are (i) antibacterial agent release (ii) contact-killing and (iii) anti-adhesion. 34 Since the properties of polymers can be tailored, surface modification by polymers is one of the promising methods adopted to achieve efficient anti-adhesive surfaces.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial polymeric paints: An up‐to‐date review

Gupta

Puttaiahgowda

Nagaraja

et al. 2021

Polymers for Advanced Techs

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A wreaking havoc condition in current urges the use of antimicrobial materials at its maximum. The various sectors such as health‐care institutions, food packaging, textile industry, water‐purification system, and so on, have high demand for the use of antimicrobial materials and paint industry is one amongst them. Since millennium, paints has been used to decorate the surroundings we live in. The transformation of use of paints can be observed from prehistoric to modern day walls as a protective and a feature enhancing substance. The paints with antimicrobial property have experienced tremendous growth to improve microbial quality in residential, commercial, institutional and industrial applications for its need to control the microbial growth which prevents the spread and reduces the risk of infections. Antimicrobial paints kill microorganisms upon contact while still retaining their durability which withstands the inevitable deterioration of paints. Antimicrobial paint additives can be easily and cost‐effectively manufactured into all types of solvent‐based, water‐based, liquid, oil or powder paints and coatings. This review provides an insight on the use of polymers in developing antimicrobial paints and their use as binder, emulsifier, latexes, varnishes, and so on, against various pathogenic waterborne and airborne microorganisms. The literature also defines the replacement of solvent‐based paints to water‐based paints which are environmentally friendly and act as good filling binder.

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Design and antimicrobial activity of piperazine polymer nanocomposite

Cited by 9 publications

References 7 publications

Antibacterial piperazine‐derived quaternized copolyesters with controlled degradability

Antibacterial piperazine‐derived quaternized copolyesters with controlled degradability

Piperazine based antimicrobial polymers: a review

Antimicrobial polymeric paints: An up‐to‐date review

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