Design and application of inorganic nanoparticles for sonodynamic cancer therapy

Abstract

This review focus on the recent developments in inorganic nanomaterials for tumor SDT.

Recent developments of sonodynamic therapy in antibacterial application

“…Some researchers revealed the working mechanisms and the current status of SDT. 23,[26][27][28][29] Nevertheless, most reviews focus on the research progress of SDT applications in tumor therapy. 10,[30][31][32] In 2021, Roy et al discussed the biophysical and chemical mechanisms of SDT, as well as detailed case studies of antibacterial SDT.…”

“…96 Recently, inorganic sonosensitizers have exhibited great potential due to their outstanding chemical/physiological properties and versatility. 29 Most studies at this stage focus on the application of inorganic sonosensitizers in the field of antitumor SDT. And some inorganic sonosensitizers have been applied in antibacterial SDT, which mainly refers to metal oxides 97 and piezoelectric materials.…”

“…Some researchers revealed the working mechanisms and the current status of SDT. 23,26–29 Nevertheless, most reviews focus on the research progress of SDT applications in tumor therapy. 10,30–32 In 2021, Roy et al .…”

Catalytically Active CoFe2O4 Nanoflowers for Augmented Sonodynamic and Chemodynamic Combination Therapy with Elicitation of Robust Immune Response

“…Sonodynamic therapy (SDT), which can generate ROS to activate cell death signaling pathways under US-triggered activation of sonosensitizers, has lately been explored as an emerging therapeutic approach for tumor treatment with minimal invasiveness and maximum tissue-penetration depth. − Traditional organic sonosensitizers suffer from poor aqueous solubility, instable chemical property, and dentrimental phototoxicity, which extremely restrict their applications in tumor therapy. In comparison, many inorganic nanomaterials ( e.g., TiO 2 and MnWO x ) have been recently explored as high-performing sonosensitizers with advantageous physicochemical properties. − As a qualified sonosensitizer, one should rapidly generate an active electron (e – )/hole (h + ) pair from the energy band structure, and subsequently convert the circumjacent H 2 O/O 2 to cytotoxic ROS. , However, the efficacy of oxygen-dependent SDT is extremely restricted by the widespread hypoxia of TME. , In this regard, it would be extremely appealing to develop high-performing sonosensitizers, not only with a narrower band gap to easily separate e – /h + but also to relieve the tumor hypoxia and break therapeutic resistance.…”

Zirconia‐Platinum Nanohybrids for Ultrasound‐Activated Sonodynamic‐Thermodynamic Bimodal Therapy by Inducing Intense Intracellular Oxidative Stress

“…Nonetheless, the evolution of more brand‐new inorganic sonosensitizers is still underway to satisfy the diverse demands in research agencies and clinics. [ 18 ] On the other hand, as another category of cytotoxic ROS, alkyl radicals generated from thermally decomposable azo initiators can also elevate oxidative stress to induce tumor cell death, and this process is irrelevant with the oxygen saturation level. [ 19–21 ] The azo salt of 2,2′‐azobis[2‐(2‐imidazolin‐2‐yl)propane] dihydrochloride (AIPH), deemed to be a heat‐liable alkyl radical generator, can be instantly disintegrated under thermal stimulation.…”