Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Abstract

Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

An X-ray activatable gold nanorod encapsulated liposome delivery system for mitochondria-targeted photodynamic therapy (PDT)

“…Furthermore, the prepared Lipo-VP-AuNRs with homogenized size below 200 nm and sable bilayer micromorphology are beneficial for normal metabolism and reducing encapsulant leakage. 35,36 Evaluation of intracellular 1…”

Cancer Immunotherapy and Cytotoxicity: Current Advances and Challenges

“…Therefore, it is of great importance for the generation of clinical-grade immune cell products based on good manufacturing practice (GMP) and convenient to universally improve life quality of patients with standard supervision. Additionally, multidisciplinary research has also highlighted the feasibility and prospective of nanomaterials (e.g., surface-conjugated nanoparticles, injectable scaffolds) as promising agents for cancer therapy attribute to the rapid progresses of nanobiotechnology and clinical biomedicine [18][19][20].…”

“…Distinguish from the conventional cancer treatment (e.g., surgery, radiotherapy and chemotherapy), noncellular immunotherapy such as checkpoint inhibitors (e.g., PD-1, PD-L1, CTLA4), lymphocyte-promoting cytokines (e.g., IFN-γ, GM-CSF, G-CSF), and cancer vaccines (e.g., mRNAs) has been continuously developed to fulfill the goals for cancer administration as well [14][15][16][17]. Additionally, current progress has also highlighted the feasibility of nanomaterials (e.g., organic nanomaterials, inorganic nanomaterials, organic-inorganic hybrid nanomaterials) as promising agents for cancer therapy based on the knowledge of nanobiotechnology and clinical biomedicine [18][19][20]. However, the significant disadvantages of the aforementioned strategies are apparent and should not be ignored including drug delivery barriers, graft-versushost disease, off-target effects and severe toxicity [5,21,22].…”

Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

“…PTAs facilitate light absorption and light conversion to heat. The ideal photothermal conversion agent should have good photostability, an NIR absorption capacity, a high PCE, and good biocompatibility [ 41 , 42 ].…”