Design and Assembly of a Bipolar Marx Generator Based on Full-Bridge Topology Applied to Electroporation

Imai, Fernando; Novaes, Yales Rômulo de

doi:10.1109/cobep/spec44138.2019.9065833

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…As a result, pulsed power electronics became an inseparable part of electroporation or techniques associated with this method. Therefore, the development of pulsed power systems for electroporation, known as electroporators, is constant [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

High Frequency Bipolar Electroporator with Double-Crowbar Circuit for Load-Independent Forming of Nanosecond Pulses

et al. 2022

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In this work, a novel electroporation system (electroporator) is presented, which is capable of forming high frequency pulses in a broad range of parameters (65 ns–100 µs). The electroporator supports voltages up to 3 kV and currents up to 40 A and is based on H-bridge circuit topology. A synchronized double crowbar driving sequence is introduced to generate short nanosecond range pulses independently of the electroporator load. The resultant circuit generates pulses with repetition frequencies up to 5 MHz and supports unipolar, bipolar, and asymmetrical pulse sequences with arbitrary waveforms. The shortest pulse duration step is hardware limited to 33 ns. The electroporator was experimentally tested on the H69AR human lung cancer cell line using 20 kV/cm bipolar and unipolar 100 ns–1 μs pulses. Based on a YO-PRO-1 permeabilization assay, it was determined that the electroporator is suitable for applied research on electroporation. The system offers high flexibility in experimental design to trigger various electroporation-based phenomena.

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Section: Introductionmentioning

confidence: 99%

High Frequency Bipolar Electroporator with Double-Crowbar Circuit for Load-Independent Forming of Nanosecond Pulses

et al. 2022

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“…Both circuits feature circuit elements, i.e., diodes and transformers, providing the required insulation between stages during pulse generation, which are stressed with a pulse voltage which is significantly higher than the stage voltage. Article [6] describes a charging circuit featuring a voltage source with a series resistor and some diodes, which bridge several stages and, hence, need to block more than only the stage voltage. In [7], a pulse transformer is used for distributing the gate signals to the generator's IGBT switches, which needs to be designed to insulate the peak pulse voltage.…”

Section: Introductionmentioning

confidence: 99%

Modelling of a Resonant Charging Circuit for a Solid-State Marx Generator

et al. 2022

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For the pulsed electric field treatment of plant material on an industrial scale, Marx-type pulse modulators are used as a pulse source. The combination of a conventional Marx generator design equipped with solid-state switches with the concept of resonant charging via current-compensated chokes enables the set-up of a Marx generator having only one active semiconductor switch per stage. Thereby, the pulse shape is defined by the passive components of the RLC-pulse circuit. In the course of the design of such a resonant charging circuit, common-mode current components through the current-compensated chokes need to be considered. Moreover, especially for a generator having its ground connection at its centre, induced voltages versus ground need to be addressed. Therefore, an investigation based on circuit simulations has been made. The simulations showed that the common-mode current components decay to zero just after the resonant charging process and cause a voltage transient at the terminal of the power supply, which needs to be floating versus ground. In order to reduce the amplitude of this transient, the effects of adding a damping resistor have been studied. However, adding this resistor may involve an increase in the common-mode current components. Moreover, the common-mode current components of different chokes are influenced by the on-time of the switches. In the paper, based on the simulation results, different operation modes with and without the damping resistor are discussed. Thereby, the on-time of the switches has been varied. Selected simulation results have been verified by means of measurements.

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Analysis of The Single Phase Bridgeless PFC Rectifier With Hybrid Switched Capacitor Cell Operating In DCM

Mumic,

Soares,

De Novaes

et al. 2023

2023 IEEE 8th Southern Power Electronics Conference and 17th Brazilian Power Electronics Conference (SPEC/COBEP)

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Design and Assembly of a Bipolar Marx Generator Based on Full-Bridge Topology Applied to Electroporation

Cited by 4 publications

References 32 publications

High Frequency Bipolar Electroporator with Double-Crowbar Circuit for Load-Independent Forming of Nanosecond Pulses

High Frequency Bipolar Electroporator with Double-Crowbar Circuit for Load-Independent Forming of Nanosecond Pulses

Modelling of a Resonant Charging Circuit for a Solid-State Marx Generator

Analysis of The Single Phase Bridgeless PFC Rectifier With Hybrid Switched Capacitor Cell Operating In DCM

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