Design and assembly of porous organic cages

Xu, Zezhao; Ye, Yangzhi; Liu, Yilan; Liu, Huiyu; Jiang, Shan

doi:10.1039/d3cc05091b

Cited by 13 publications

(4 citation statements)

References 162 publications

(267 reference statements)

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“…4,5 This makes them highly attractive for various biological applications and catalysis. 6,7 These cages can be meticulously designed to present well-defined binding pockets within their cavities, customizable in terms of size, topology, and specific functional groups strategically positioned toward the interior. By manipulating the cage size and structure, a high level of control over the binding environment can be achieved by rivaling naturally occurring enzymes.…”

Section: Introductionmentioning

confidence: 99%

“…Organic cages, characterized by their tailorable structures and prefunctionalized moieties, are emerging as versatile tools to address challenges in gas separation, medicine, and beyond. − Due to the self-assembly of small organic molecules, these cages feature internal cavities capable of encapsulating guest molecules and metal nanoparticles. , This makes them highly attractive for various biological applications and catalysis. , These cages can be meticulously designed to present well-defined binding pockets within their cavities, customizable in terms of size, topology, and specific functional groups strategically positioned toward the interior. By manipulating the cage size and structure, a high level of control over the binding environment can be achieved by rivaling naturally occurring enzymes.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Applications of Cage-Based Covalent Organic Frameworks

Dutta,

Hernández García,

Mishra

et al. 2024

Crystal Growth & Design

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Due to their unique structural characteristics, molecular cages have become pivotal components in supramolecular chemistry and materials science. These cages possess the remarkable ability to encapsulate guest molecules and metal nanoparticles within their cavities, fostering intriguing host−guest interactions and demonstrating significant potential across various domains, including molecular recognition, drug delivery, catalysis, and material synthesis. Integrating these molecular cages with highly porous crystalline covalent organic frameworks (COFs) constitutes a strategic avenue for enhancing both porosity and functional sites. This transition from molecular cages to COF frameworks involves the precise orchestration of individual molecules into extended, covalently bonded structures with welldefined frameworks and porosity. This unlocks novel pathways for materials design and applications, significantly enriching the landscape of materials science. This review comprehensively summarizes the synthetic strategies employed in fabricating cage-based COFs, explores their diverse applications, and provides insights into the future prospects and growth of this rapidly evolving field.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Applications of Cage-Based Covalent Organic Frameworks

Dutta,

Hernández García,

Mishra

et al. 2024

Crystal Growth & Design

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“…Moving beyond extended frameworks, the application of reticular chemistry principles to the rational design and synthesis of discrete structures, such as metal–organic cages − and porous organic cages, − represents a burgeoning frontier. These discrete entities offer distinctive advantages, such as meticulous control over shape and size, extensive opportunities for functional modification, and inherent solution processability, positioning them as key components for a variety of applications from catalysis , and gas separation − to drug delivery , and sensing. − Despite the clear potential, a systematic exploration of discrete structures through the lens of reticular chemistry remains sparse .…”

Section: Introductionmentioning

confidence: 99%

Isoreticular Covalent Organic Pillars: Engineered Nanotubular Hosts for Tailored Molecular Recognition

Gao,

Guo,

Xue

et al. 2024

J. Am. Chem. Soc.

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In the realm of nanoscale materials design, achieving precise control over the dimensions of nanotubular architectures poses a substantial challenge. In our ongoing pursuit, we have successfully engineered a novel class of single-molecule nanotubes�isoreticular covalent organic pillars (iCOPs)�by stacking formylated macrocycles through multiple dynamic covalent imine bonds, guided by principles of reticular chemistry. Our strategic selection of rigid diamine linkers has facilitated the synthesis of a diverse array of iCOPs, each retaining a homologous structure yet offering distinct cavity shapes influenced by the linker choice. Notably, three of these iCOP variants feature continuous one-dimensional channels, exhibiting length-dependent host−guest interactions with α,ω-dibromoalkanes, and each presenting a distinct critical guest alkyl chain length threshold for efficient guest encapsulation. This newfound capability not only provides a platform for tailoring nanotubular structures with precision, but also opens new avenues for innovative applications in molecular recognition and the purification of complex mixtures.

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“…Porous organic cages (POCs) are low-density porous materials with discrete pore structures constructed by dynamic covalent bonds. 16,17 The discrete nature endows this material with unique characteristics distinguishing it from other materials, that is high dispersion in solution which greatly facilitates the preparation of devices and the formation of membranes of such materials. To date, POCs have been employed as a research platform in a number of fields, including gas adsorption separation, 18,19 molecular recognition, 20 capacity storage, 21 and conversion.…”

mentioning

confidence: 99%