Design and characterisation of a microconcentric nebuliser interface for capillary electrophoresis-inductively coupled plasma mass spectrometry

Taylor, Karen A.; Sharp, Barry L.; Lewis, John; Crews, Helen M.

doi:10.1039/a803822h

Cited by 94 publications

(85 citation statements)

References 36 publications

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“…An interface constructed from a stainless-steel union and tube 15,17 was investigated in preliminary studies. ICP-MS backgrounds were unacceptable (above 5000 counts s…”

Section: Resultsmentioning

confidence: 99%

Application of capillary electrophoresis interfaced to double focusing sector field ICP-MS for nuclide abundance determination of lanthanides produced via spallation reactions in an irradiated tantalum target

Day

Caruso

Becker

et al. 2000

J. Anal. At. Spectrom.

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An analytical procedure was developed using capillary electrophoresis (CE) coupled on-line to a doublefocusing sector ®eld inductively coupled plasma mass spectrometer (DF-ICP-MS) for the analysis of mixtures of lanthanide elements in aqueous samples with natural isotope abundances and in a sample taken from an irradiated tantalum target containing arti®cial nuclide abundances. A MicroMist AR30-1-F02 nebulizer with a Cinnabar small volume cyclonic spray chamber was used for ICP-MS sample introduction. The CE-ICP-MS interface featured a self-aspirating electrolyte make-up solution for electrical ground connection and control of nebulizer suction. The CE-ICP-MS method features fast run times and small sample sizes (#35 nL injection volume). Detection limits for the most abundant lanthanide isotopes were 0.72 ppb to 3.9 ppb, an improvement of as much as one order of magnitude compared to a quadrupole ICP-MS system using a similar experimental arrangement. Abundances of the most abundant isotopes of lanthanides were found to be within 0.1±2% of table values for natural samples while isotopes present in smaller amounts were within 3±5% of table values. The method was applied to samples taken from a tantalum material which was exposed to a high energy proton beam for the production of neutrons via spallation reactions. A large fraction of the spallation products were lanthanides containing nuclide abundances unlike natural samples. Thus, a chemical separation step prior to ICP-MS detection was required to avoid isobaric interferences for the accurate determination of nuclide abundances in such samples. The results of the nuclide abundance determinations were compared to theoretical calculations.

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“…An interface constructed from a stainless-steel union and tube 15,17 was investigated in preliminary studies. ICP-MS backgrounds were unacceptable (above 5000 counts s…”

Section: Resultsmentioning

confidence: 99%

Application of capillary electrophoresis interfaced to double focusing sector field ICP-MS for nuclide abundance determination of lanthanides produced via spallation reactions in an irradiated tantalum target

Day

Caruso

Becker

et al. 2000

J. Anal. At. Spectrom.

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“…46,47,[64][65][66][67][68][69][70][71][72] Even though a number of interface designs have been suggested during the last decade, to address the mentioned challenges, most recent applications utilize commercially available interface systems. 46,47,73 In summary it must be said that despite the exceptional separation capabilities of CE and the high-level research studies that utilize CE-ICP-MS, more developments are necessary to make CE-ICP-MS a technique suitable for routine analysis.…”

Section: Icp-ms Fundamentalsmentioning

confidence: 99%

“…108,[180][181][182] Based on this development, Prange and Schaumlöffel et al pioneered the field of sulfur isotopedilution analysis by combining postcolumn non-species-specific isotope dilution and capillary electrophoresis hyphenated to sector field ICP-MS for the highly resolved separation of different metallothionein (MT) isoforms, which allowed determination of the metal stoichiometry of the different isoforms as well as their absolute quantification. 183,184 A non-species-specific element spike containing 34 S, 65 Cu, 68 Zn, and 116 Cd introduced via the make-up flow of the CE interface was used for on-line isotope ratio measurement of 32 S/ 34 S, 63 Cu/ 65 Cu, 64 Zn/ 68 Zn, and 114 Cd/ 116 Cd. Reversed isotope dilution, using a standard solution containing S, Cu, Zn, and Cd with natural isotopic abundances, has been used for mass flow calibration of the different elements.…”

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confidence: 99%

Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) for Quantitative Analysis in Environmental and Life Sciences: A Review of Challenges, Solutions, and Trends

2012

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This focal point review provides an overview of recent developments and capabilities of inductively coupled plasma mass spectrometry (ICP-MS) coupled with different separation techniques for applications in the fields of quantitative environmental and bio-analysis. Over the past years numerous technical improvements, which are highlighted in this review, have helped to promote the evolution of ICP-MS to one of the most versatile tools for elemental quantification. In particular, the benefits and possibilities of using state-of-the-art hyphenated ICP-MS approaches for quantitative analysis are demonstrated with a focus on environmental and bio-analytical applications.

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“…Para aumentar a eficiência de nebulização, vários autores vêm propondo o uso dos nebulizadores micro-concêntricos e do HEN que trabalham com fluxos menores, µL min -1 , mas que ainda são altos comparados com as vazões da CE [43][44][45][46] . Uma segunda limitação do acoplamento CE-ICP-MS é a alta concentração de sais na solução devido ao eletrólito ou tampão de análise 47 .…”

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Eletroforese capilar acoplada à espectrometria com plasma: uma ferramenta eficiente para a especiação

et al. 2003

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Recebido em 26/11/01; aceito em 25/7/02 CAPILLARY ELECTROPHORESIS COUPLED TO PLASMA SPECTROMETRY: AN EFFICIENT TOOL FOR SPECIATION. The most important features of the CE-ICP hyphenation, as well as its advantages and drawbacks as a tool for speciation are discussed. The fundamental principles of capillary electrophoresis and inductively coupled plasma mass spectrometry are also presented. Some applications involving different designs proposed in the literature to couple CE and ICP system for elemental speciation are reviewed.Keywords: speciation; CE-ICP-MS; CE-ICP-OES. INTRODUÇÃOOs metais pesados, largamente utilizados pela indústria, normalmente, não se encontram como íons livres ou em sua forma original no ambiente mas, ocorrem como parte de espécies químicas que são resultantes de uma série de processos naturais bio-geo-químicos, associados ou não às interferências humanas 1 . Isso significa que as diversas espécies de um mesmo elemento apresentam comportamentos diferenciados, o que pode comprometer a exatidão do método durante sua determinação 2 . Percebe-se, portanto, que é necessário fazer, além da determinação quantitativa total dos elementos presentes nas diferentes amostras, a identificação de cada espécie.As principais áreas de interesse da especiação envolvem o monitoramento da poluição nos solos, ar, águas, sedimentos e biota por espécies organometálicas e inorgânicas tóxicas. Muitos estudos relacionados à biometilação de metais (especialmente mercúrio) e semi-metais (arsênio e selênio) têm sido feitos, uma vez que estes elementos podem apresentar um alto nível de toxidez, dependendo do estado de oxidação em que se encontram 3 . Além disso, deve ser considerado que o estudo da cinética de elementos traços no corpo humano, devido à exposição aos metais, não seria possível sem as informações fornecidas pela especiação.O controle homeostático e metabolização de elementos essenciais, como zinco e cobre, e dos tóxicos, como mercúrio e arsênio, por organismos da biota também têm sido objeto de muitos estudos devido à importância econômica e às implicações ambientais da utilização desses elementos. Uma das áreas de maior interesse, no campo da especiação, é aquela relacionada às metalotioneínas (MT), as quais são um grupo de proteínas, não-enzimáticas, de baixa massa molar, ricas em cisteínas, resistentes à termo-coagulação e à precipitação ácida e que possuem um ligante metálico em sua estrutura. A principal característica das metalotioneínas é formar complexos com os metais bivalentes e complexos metal-tiol. Decorrente dessa característica, em sistemas biológicos, a síntese da proteína só ocorre induzida por metais 4 . Devido à importância das MT em sistemas biológicos, a escolha e otimização de sistemas acoplados para a determinação dos diferentes complexos com os metais ainda é motivo de vários estudos. Uma vez que as MT, para os diferentes organismos, possuem diferentes isoformas, a identificação e determinação de uma isoforma podem contribuir para uma melhor compreensão do papel e funções das isoforma...

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Design and characterisation of a microconcentric nebuliser interface for capillary electrophoresis-inductively coupled plasma mass spectrometry

Cited by 94 publications

References 36 publications

Application of capillary electrophoresis interfaced to double focusing sector field ICP-MS for nuclide abundance determination of lanthanides produced via spallation reactions in an irradiated tantalum target

Application of capillary electrophoresis interfaced to double focusing sector field ICP-MS for nuclide abundance determination of lanthanides produced via spallation reactions in an irradiated tantalum target

Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) for Quantitative Analysis in Environmental and Life Sciences: A Review of Challenges, Solutions, and Trends

Eletroforese capilar acoplada à espectrometria com plasma: uma ferramenta eficiente para a especiação

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