Design and characterization of a novel 3D printed pressure-controlled drug delivery system

Krause, Julius; Bogdahn, Malte; Schneider, Felix; Koziolek, Mirko

doi:10.1016/j.ejps.2019.105060

Cited by 34 publications

(21 citation statements)

References 33 publications

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“…On the other hand, ERS was used as the main polymer by Krause et al (2019) in the 3D printing of an acetaminophen innovative pressure-controlled drug delivery system. This polymer was selected due to its insolubility in water, pH independent swelling properties and low permeability.…”

Section: Fused Deposition Modelingmentioning

confidence: 99%

“…This polymer was selected due to its insolubility in water, pH independent swelling properties and low permeability. In addition, its choice was also based on the ability of ERS100 to produce brittle capsule shells that would break in pressure conditions, affording immediate drug release under physiological conditions in the gastric environment [ 155 ]. Similarly to ERL, ERS has been also used in the 3D printing of controlled/sustained drug release formulations, like implants [ 151 ], or in blends with other polymer families [ 152 , 153 ].…”

Section: 3d Printingmentioning

confidence: 99%

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Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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Section: Fused Deposition Modelingmentioning

confidence: 99%

Section: 3d Printingmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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“…The modification of the printer consisted of a rigid transparent tube that was screwed onto the print head, as previously described. 21 Commercially available PLA filament was used as feed filament. The hot end was equipped with a nozzle with a diameter of 0.25 mm.…”

Section: Pressure Sensitive Capsulementioning

confidence: 99%

“…18e20 Krause et al designed a 3D printed pressure sensitive capsule aiming to release its content in the antropyloric region of the GI tract in response to the high-pressure event of transit through the pylorus, or the MMC phase III contractions pressing the capsule against the closed pylorus. 21 The brittle capsule was designed to shatter into pieces when exposed to a pressure higher than 300 mbar, instantaneously delivering its content. This trigger pressure was chosen based on GI pressure data 22e24 and defined to allow the capsule to maintain its integrity in the stomach while being crushed when exposed to the higher pressure in the antropyloric region related to gastric emptying.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Berg

Krause

Björkbom

et al. 2021

Journal of Pharmaceutical Sciences

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In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive capsules were compared to traditional enteric coated hard gelatin capsules and enteric coated tablets. Paracetamol, which is completely absorbed in dogs, was included in the formulations and used as an absorption marker to give information about the in vivo performance of the dosage forms. The pressure sensitive capsules released drug in 50% of the dogs. In the cases where drug was released, there was no difference in octreotide bioavailability or C max compared to the enteric coated dosage forms. When comparing all dosage forms, a correlation was seen between paracetamol C max and octreotide bioavailability, suggesting that a high drug release rate may be beneficial for peptide absorption when delivered together with sodium caprate.

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“…Fused Deposition Modelling Fused deposition modelling has been applied widely in manufacturing of novel pharmaceutical dosage forms. [47][48][49][50][51][52][53][54][55] Filaments (typically 1.75-3 mm) are feedstock of conventional FDM 3D printers. In these printers, the filament passes through a tubing system and rotating pulleys/gears in the 3D printer head, which melts and extrudes the filament through a narrow nozzle (typically 0.4 mm diameter).…”

Section: Inkjet 3dpmentioning

confidence: 99%

Next Steps in 3D Printing of Fast Dissolving Oral Films for Commercial Production

Ehtezazi

Algellay

Hardy

2020

DDF

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: 3D printing technique has been utilised to develop novel and complex drug delivery systems that are almost impossible to produce by employing conventional formulation techniques. For example, this technique may be employed to produce tablets or fast dissolving oral films (FDFs) with multilayers of active ingredients, which are personalised to patient’s needs. In this article, we compared the production of FDFs by 3D printing to conventional methods such as solvent casting. Then, we evaluated the need for novel methods of producing fast dissolving oral films; and why 3D printing may be able to meet the short falls of FDF production. The challenges of producing 3D printed FDFs are identified at commercial scale by referring to the identification of suitable materials, hardware, quality control tests and Process Analytical Technology. In this paper we discuss that the FDF market will grow to more than $1.3 billion per annum in next few years and 3D printing of FDFs may share part of this market. Although, companies are continuing to invest in technologies which provide alternatives to standard drug delivery systems, the market for thin film products is already well established. Market entry for a new technology such as 3D printing of FDFs will, therefore, be hard, unless, this technology proves to be a game changer. A few approaches are suggested in this paper.

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Design and characterization of a novel 3D printed pressure-controlled drug delivery system

Cited by 34 publications

References 33 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Next Steps in 3D Printing of Fast Dissolving Oral Films for Commercial Production

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