Design and characterization of antitumor drug paclitaxel-loaded chitosan nanoparticles by W/O emulsions

Xu, Jiarui; Ma, Lili; Liu, Yang; Xu, Fei; Nie, Jun; Ma, Guiping

doi:10.1016/j.ijbiomac.2011.12.034

Cited by 59 publications

(26 citation statements)

References 30 publications

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“…7 If 5-FU were carried by CTS or its derivatives, the result would be extended release, improved bioavailability, and reduced side effects. [8][9][10] Carrier agents, such as CTS, also have adhesion and biodegradability properties that give them the potential to improve drug efficacy.…”

Section: Introductionmentioning

confidence: 99%

Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics

Cheng¹,

Chen²,

Wang³

et al. 2014

IJN

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The nanoparticle drug delivery system, which uses natural or synthetic polymeric material as a carrier to deliver drugs to targeted tissues, has a broad prospect for clinical application for its targeting, slow-release, and biodegradable properties. Here, we used chitosan (CTS) and hepatoma cell-specific binding molecule glycyrrhetinic acid to synthesize glycyrrhetinic acid-modified chitosan (GA-CTS). The synthetic product was confirmed by infrared (IR) spectra and hydrogen-1 nuclear magnetic resonance. The GA-CTS/5-fluorouracil (5-FU) nanoparticles were synthesized by combining GA-CTS and 5-FU and conjugating 5-FU onto the GA-CTS nanomaterial. The central composite design was performed to optimize the preparation process as CTS:tripolyphosphate sodium (TPP) weight ratio =5:1, 5-FU:CTS weight ratio =1:1, TPP concentration =0.05% (w/v), and cross-link time =50 minutes. GA-CTS/5-FU nanoparticles had a mean particle size of 193.7 nm, a polydispersity index of 0.003, a zeta potential of +27.4 mV, and a drug loading of 1.56%. The GA-CTS/5-FU nanoparticle had a protective effect on the drug against plasma degrading enzyme, and provided a sustained release system comprising three distinct phases of quick, steady, and slow release. Our study showed that the peak time, half-life time, mean residence time and area under the curve of GA-CTS/5-FU were longer or more than those of the 5-FU group, but the maximum concentration (C max ) was lower. We demonstrated that the nanoparticles accumulated in the liver and have significantly inhibited tumor growth in an orthotropic liver cancer mouse model.

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Section: Introductionmentioning

confidence: 99%

Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics

Cheng¹,

Chen²,

Wang³

et al. 2014

IJN

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“…Emulsion method in earlier studies using poly (vinyl alcohol) (PVA1) [29], polysorbate 80 [30], Span80 [31], PVA [32], PVA [33], and Tween 80 [34] surfactants have resulted in average sizes (particle diameter) of 900 nm, 50 nm, 496 nm, 700 nm, 119 nm, 226, and 102 nm, respectively. The mini-emulsion polymerization procedure followed is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of paclitaxel in ultra-fine nanoparticles of acrylic/styrene terpolymer for controlled release

Rajaee

Farzi

2015

Colloid Polym Sci

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Paclitaxel (PTX) is one of the most utilized anticancer drugs with a broad spectrum of antitumor activity. PTX is usually formulated in Cremopher EL because it suffers from low solubility in water and has many side effects. Low solubility leads to encapsulation and controlled release of PTX being a rough process. In this study, a simple method was used for nano-encapsulation of PTX into three different types of ultra-fine polymeric particles. These include poly (methyl methacrylate) (PMMA), poly (styrene) (PST) and poly (methyl methacrylate-co-styrene) (P(MMA-ST-AA)) with several monomer ratios. Different drug contents in the monomer have been investigated. Synthesis was performed via the miniemulsion polymerization method, and the results proved that PTX was encapsulated into spherical ultra-fine PA/PS nanoparticles of approximately 19 nm.

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“…[18,19] It is extracted from the bark of Yew tree [20] and is used alone or in combination with other chemotherapeutics [21] to treat many types of cancer cells such as breast, [22] ovarian, [23] and lung cancers. [24] Some nanoparticle drug carriers functionalised with Taxol have been investigated for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Effect of Modification Protocols on the Effectiveness of Gold Nanoparticles as Drug Delivery Vehicles for Killing of Breast Cancer Cells

et al. 2016

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The current study evaluated the potential of gold nanoparticles (AuNPs) for the delivery of Taxol to breast cancer cells (T47D) using an in vitro cell culture model. For this study, new loading approaches and novel chemical attachments were investigated. Five different gold nanoparticle-based complexes were used to determine their cytotoxicity towards T47D cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) viability assay. There was no significant decrease (P . 0.05) in cell viability when T47D cells were treated with AuNPs that did not contain Taxol. However, cells were significantly killed by gold nanoparticles chemically conjugated to Taxol using three different approaches and one novel hybrid AuNP-Taxol nanoparticle, wherein no chemical bonds were involved. These Taxolloaded AuNPs were more effective at inducing cell death in vitro than a solution of free Taxol used to treat cells. This result demonstrated that Taxol could be released from the particles in the cell culture media for subsequent therapeutic action. Additionally, the experiments proved that the Taxol-loaded AuNPs were more toxic in a dose dependent manner than Taxol as a formulation for the treatment of breast cancer cells. The results of this study suggest that gold nanoparticles have potential for the efficient delivery of Taxol to breast cancer cells. This could provide a future solution as an alternative application method to overcome adverse side effects resulting from current high-dose treatment regimes.

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Design and characterization of antitumor drug paclitaxel-loaded chitosan nanoparticles by W/O emulsions

Cited by 59 publications

References 30 publications

Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics

Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics

Encapsulation of paclitaxel in ultra-fine nanoparticles of acrylic/styrene terpolymer for controlled release

Effect of Modification Protocols on the Effectiveness of Gold Nanoparticles as Drug Delivery Vehicles for Killing of Breast Cancer Cells

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