Design and Characterization of Finger-Controlled Micropump for Lab-on-a-Chip Devices

Abstract

A microfluidic device that can be operated by simple finger squeezing, without the aid of any extra power, i.e. electricity or a battery, present advantages for diagnostic applications. It is particularly true for diagnostic kits intended to be used in remote areas with limited access to electricity. In this paper, we describe a simple design and manufacturing of a finger pump that relies on an optimised network of check valves and squeeze pumps. The results show that the pump is capable of flowing liquid specimen with a volume of 6 mL with a finger pump priming force of around 3 N. The finger pump is intended to be used in a diagnostic kit.

A Preliminary Conceptual Design Approach of Food Waste Composter Design

“…The earliest design process involved the basic calculation of the food waste volume capacity, the heating capacity, and the power needed from the auxiliary components. The theoretical calculation concept had been applied in other design processes, such as in calculating the thermodynamic process to design a geothermal power plant 20) and solar AC system 21) , with the combination of simulation through designing a micropump 22) , and designing a wind turbine for low Reynolds number 23) .…”

Biosensors-on-Chip: An Up-to-Date Review

“…Furthermore, micropumps and microvalves are key components for microfluidics-based analytical systems, especially in multi-step chemical reactions and quantitative analyses, as they enable complex biochemical assay automation [ 45 , 46 ]. On the one hand, micropumps are an integral part of microfluidic systems, as they allow for the precise, accurate, and reliable control of fluid transport through the device [ 45 , 47 , 48 ]. Moreover, they are capable of transferring fixed amounts of the fluid to the reaction unit for undergoing mixing, separation, or sensing processes [ 49 ].…”

“…Additionally, since active micropumps require external energy supplies, which make them unsuitable for PoC applications, passive micropumps, which circumvent limitations related to power consumption, actuation mechanism integration, and pulsating or oscillating flows, are preferred for BoC development [ 47 , 48 ]. Among them, pneumatic-driven micropumps, which use compressed air for fluid driving, are the most commonly used [ 45 ]. On the other hand, microvalves are also fundamental for microfluidic systems, as their functions involve flow regulation, biomolecule, nanoparticle, or reagents isolation, and on/off switching [ 43 , 50 ].…”

Radical Scavenging Activity Assay and Red Fluorescence Microscopy Studies: Antioxidant Properties of Selected Young and Mature Leaves for Application in Pharmaceutical Industry

“…In general, the TAC values roughly show the same and across the plant family. Thus, this method would be potentially applicable as a green and non-invasive of lab-on-chip device 28) to screen the antioxidant capacity of leaves from various plant families and other possible agricultural applications 29) .…”