Design and Characterization of Spray-Dried Chitosan-Naltrexone Microspheres for Microneedle-Assisted Transdermal Delivery

Ogunjimi, Abayomi Tolulope; Fiegel, Jennifer; Brogden, Nicole K.

doi:10.3390/pharmaceutics12060496

Cited by 19 publications

(15 citation statements)

References 49 publications

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“…Higher feed viscosity leads to the formation of larger droplets, and as a consequence, particles obtained during the spray drying process were characterized by larger diameters. A comparable result was observed in work of Ogunjim et al [ 31 ], where the spray drying of different chitosan solutions with low (0.5% w /v ), medium (0.7% w /v ) and high (0.9% w /v ) concentrations significantly affected microspheres size.…”

Section: Resultssupporting

confidence: 89%

The Impact of Gelatin on the Pharmaceutical Characteristics of Fucoidan Microspheres with Posaconazole

et al. 2021

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Fungal infections and invasive mycoses, despite the continuous medicine progress, are an important globally therapeutic problem. Multicompartment dosage formulations (e.g., microparticles) ensure a short drug diffusion way and high surface area of drug release, which as a consequence can provide improvement of therapeutic efficiency compared to the traditional drug dosage forms. As fucoidan is promising component with wide biological activity per se, the aim of this study was to prepare fucospheres (fucoidan microparticles) and fucoidan/gelatin microparticles with posaconazole using the one-step spray-drying technique. Pharmaceutical properties of designed fucospheres and the impact of the gelatin addition on their characteristics were evaluated. An important stage of this research was in vitro evaluation of antifungal activity of developed microparticles using different Candida species. It was observed that gelatin presence in microparticles significantly improved swelling capacity and mucoadhesiveness, and provided a sustained POS release. Furthermore, it was shown that gelatin addition enhanced antifungal activity of microparticles against tested Candida spp. strains. Microparticles formulation GF6, prepared by the spray drying of 20% fucoidan, 5% gelatin and 10% Posaconazole, were characterized by optimal mucoadhesive properties, high drug loading and the most sustained drug release (after 8 h 65.34 ± 4.10% and 33.81 ± 5.58% of posaconazole was dissolved in simulated vaginal fluid pH 4.2 or 0.1 M HCl pH 1.2, respectively).

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Section: Resultssupporting

confidence: 89%

The Impact of Gelatin on the Pharmaceutical Characteristics of Fucoidan Microspheres with Posaconazole

et al. 2021

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“…Spray drying is a continuous and scalable drying process to encapsulate materials, the process can generate nano to micron size particles that have a narrow distribution in a very short time. [108] It has been used in pharmaceutical processing [109][110][111] and food industry [112] for a long time. The main advantage of spray drying is the waste reduction and high efficiency of raw material.…”

Section: Physical Methodsmentioning

confidence: 99%

Fabrication of Organic Shape-stabilized Phase Change Material and Its Energy Storage Applications

Hu¹,

Wu²,

Liu³

et al. 2021

Eng. Sci.

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Organic phase change materials (OPCMs) are advanced energy storage materials with ability to storage and release thermal energy at constant temperature. Efficient energy storage systems using shape-stabilized PCMs (SSPCMs) are promising to adjust the gap between energy supply and demand. The performances of SSPCMs are influenced by multiple factors which are necessary to be considered in the fabrication process. In this regard, we summarized the desired properties for OPCMs and SSPCMs, then we systematically discussed the fabrication methods involving supporting materials, OPCMs and fillers. At last, we elaborated thermal storage applications of SSPCMs from three kinds of energy sources. This review intends to provide in-depth and constructive insights into the fabrication and energy storage applications of SSPCMs, thereby contributing to development and application of high-performance SSPCMs.

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“…Dried samples were mounted on double-sided adhesive carbon tabs mounted on Scanning Electron Microscopy (SEM) stubs and coated with gold/palladium and viewed under a JEOL 5600 (JEOL, Tokyo, Japan) scanning electron microscope at an accelerating voltage of 20 kV. Microcapsule size was determined using ImageJ (1.52 a; ), (accessed on 15 March 2022) resulting from the average of 400 measurements [ 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Spray-Drying Encapsulation of the Live Biotherapeutic Candidate Akkermansia muciniphila DSM 22959 to Survive Aerobic Storage

et al. 2022

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Akkermansia muciniphila is regarded as a promising next-generation probiotic or live biotherapeutic candidate. Effective delivery strategies must be developed to ensure high enough viability of the probiotic strain throughout its industrial formulation, distribution chain, shelf-life, and, ultimately, the host’s gastrointestinal tract, where it should exert its beneficial effect(s). Among the possible methodologies, spray-drying is considered industrially attractive regarding its costs, efficiency, and scalability, with the due parameter customization. In this study, spray-drying was explored as a one-step process to encapsulate A. muciniphila DSM 22959, testing the drying settings and three different dairy-based matrices. Microcapsule morphology and size was assessed, and viability throughout storage at 4 or 22 °C and simulated gastrointestinal passage was determined. Akkermansia muciniphila microencapsulation by spray-drying, using 10% skim milk and inlet/outlet temperatures of 150/65 °C, is effective in terms of viability stabilization, both during prolonged aerobic storage and exposure to simulated gastrointestinal passage. Akkermansia muciniphila viability was maintained at around 107 CFU/g up to 28 days at 4 °C under aerobic conditions with viability losses inferior to 1 log reduction. This methodology provides the necessary conditions to efficiently deliver the recommended dose of live A. muciniphila in the human gut as a live biotherapeutic product.

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Design and Characterization of Spray-Dried Chitosan-Naltrexone Microspheres for Microneedle-Assisted Transdermal Delivery

Cited by 19 publications

References 49 publications

The Impact of Gelatin on the Pharmaceutical Characteristics of Fucoidan Microspheres with Posaconazole

The Impact of Gelatin on the Pharmaceutical Characteristics of Fucoidan Microspheres with Posaconazole

Fabrication of Organic Shape-stabilized Phase Change Material and Its Energy Storage Applications

Spray-Drying Encapsulation of the Live Biotherapeutic Candidate Akkermansia muciniphila DSM 22959 to Survive Aerobic Storage

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