Design and Development of a Traveling Wave Ferro-Microfluidic Device and System Rig for Potential Magnetophoretic Cell Separation and Sorting in a Water-Based Ferrofluid

Hewlin, Rodward L.; Edwards, Maegan; Schultz, Christopher J.

doi:10.3390/mi14040889

Cited by 16 publications

(8 citation statements)

References 37 publications

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“…The relevance of magnetic nano- and micro-particles has increased over the last decade, as they have revolutionized many areas, including medicine (e.g., cancer theragnostic, biosensing, catalysis), agriculture, and the environment [ 29 , 77 ]. Here, we used flow cells and urinary catheters to prove the concept of using SMARTFs for biofilm removal.…”

Section: Discussionmentioning

confidence: 99%

“…The major areas are mechanical engineering and automotive, military and defense, optics, aerospace, water treatment, cosmetics, and biomedical [ 26 ]. Among biomedical applications, the most interesting are prosthetics and exoskeletons, biosensors and bioimaging technologies, hyperthermia therapy, anticancer drug delivery, antimicrobial activity, and diagnostic microfluidic devices (lab-on-chip) [ 26 , 28 , 29 ]. The toxicity of ferrofluid is very low; animal experiments in which the permissible maximum doses of ferrofluid were either administered orally, intravenously, or intraperitoneally did not kill the mice [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Using SMART Magnetic Fluids and Gels for Prevention and Destruction of Bacterial Biofilms

Krol

Ehrlich

2023

Microorganisms

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Biofouling is a major problem in all natural and artificial settings where solid surfaces meet liquids in the presence of living microorganisms. Microbes attach to the surface and form a multidimensional slime that protects them from unfavorable environments. These structures, known as biofilms, are detrimental and very hard to remove. Here, we used SMART magnetic fluids [ferrofluids (FFs), magnetorheological fluids (MRFs), and ferrogels (FGs) containing iron oxide nano/microparticles] and magnetic fields to remove bacterial biofilms from culture tubes, glass slides, multiwell plates, flow cells, and catheters. We compared the ability of different SMART fluids to remove biofilms and found that commercially available, as well as homemade, FFs, MRFs, and FGs can successfully remove biofilm more efficiently than traditional mechanical methods, especially from textured surfaces. In tested conditions, SMARTFs reduced bacterial biofilms by five orders of magnitude. The ability to remove biofilm increased with the amount of magnetic particles; therefore, MRFs, FG, and homemade FFs with high amounts of iron oxide were the most efficient. We showed also that SMART fluid deposition can protect a surface from bacterial attachment and biofilm formation. Possible applications of these technologies are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Using SMART Magnetic Fluids and Gels for Prevention and Destruction of Bacterial Biofilms

Krol

Ehrlich

2023

Microorganisms

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“…Magnetic nanoparticles (MNPs) are nanoscale materials with exceptional properties that find applications across diverse fields, including environmental, biomedical, and clinical domains [1][2][3][4][5][6]. The size range of MNPs is comparable to that of viruses (20-500 nm), proteins (5-50 nm), or genes (2 nm wide and 10-200 nm long).…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Beković,

Ban,

Drofenik

et al. 2023

Applied Sciences

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This concise review delves into the realm of superparamagnetic nanoparticles, specifically focusing on Fe2O3, Mg1+xFe2−2xTixO4, Ni1−xCux, and CrxNi1−x, along with their synthesis methods and applications in magnetic hyperthermia. Remarkable advancements have been made in controlling the size and shape of these nanoparticles, achieved through various synthesis techniques such as coprecipitation, mechanical milling, microemulsion, and sol–gel synthesis. Through this review, our objective is to present the outcomes of diverse synthesis methods, the surface treatment of superparamagnetic nanoparticles, their magnetic properties, and Curie temperature, and elucidate their impact on heating efficiency when subjected to high-frequency magnetic fields.

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“…CTCs are known to disseminate to distant sites in the body through the bloodstream as part of the cancer metastatic process and are often found in extremely low numbers, with fewer than 100 CTCs or 10 clusters per 10 million leukocytes and 5 billion erythrocytes in 1 mL of whole blood [ 12 ]. While immunoselection [ 13 , 14 ], magnetophoresis [ 15 , 16 , 17 , 18 , 19 ], or dielectrophoresis [ 20 , 21 ] can be used to isolate these rare cells directly from blood, microfluidic size-based physical cell traps have emerged as a popular alternative.…”

Section: Introductionmentioning

confidence: 99%

Numerical Modeling of Physical Cell Trapping in Microfluidic Chips

Cardona,

Mostafazadeh,

Luan

et al. 2023

Micromachines

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Microfluidic methods have proven to be effective in separation and isolation of cells for a wide range of biomedical applications. Among these methods, physical trapping is a label-free isolation approach that relies on cell size as the selective phenotype to retain target cells on-chip for follow-up analysis and imaging. In silico models have been used to optimize the design of such hydrodynamic traps and to investigate cancer cell transmigration through narrow constrictions. While most studies focus on computational fluid dynamics (CFD) analysis of flow over cells and/or pillar traps, a quantitative analysis of mechanical interaction between cells and trapping units is missing. The existing literature centers on longitudinally extended geometries (e.g., micro-vessels) to understand the biological phenomenon rather than designing an effective cell trap. In this work, we aim to make an experimentally informed prediction of the critical pressure for a cell to pass through a trapping unit as a function of cell morphology and trapping unit geometry. Our findings show that a hyperelastic material model accurately captures the stress-related softening behavior observed in cancer cells passing through micro-constrictions. These findings are used to develop a model capable of predicting and extrapolating critical pressure values. The validity of the model is assessed with experimental data. Regression analysis is used to derive a mathematical framework for critical pressure. Coupled with CFD analysis, one can use this formulation to design efficient microfluidic devices for cell trapping and potentially perform downstream analysis of trapped cells.

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Design and Development of a Traveling Wave Ferro-Microfluidic Device and System Rig for Potential Magnetophoretic Cell Separation and Sorting in a Water-Based Ferrofluid

Cited by 16 publications

References 37 publications

Using SMART Magnetic Fluids and Gels for Prevention and Destruction of Bacterial Biofilms

Using SMART Magnetic Fluids and Gels for Prevention and Destruction of Bacterial Biofilms

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Numerical Modeling of Physical Cell Trapping in Microfluidic Chips

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