Design and Development of a Disposable Lab-on-a-Chip for Prostate Cancer Detection

Farazmand, Meer H.; Rodrigues, Rui; Gardner, Julian W.; Charmet, Jérôme

doi:10.1109/embc.2019.8857072

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…6,7 As a new technology, microuidic chips have become an ideal platform for the development of tumor marker detection technologies due to their micro scale effect, simple operation, easy to realize automation and integration, convenience for high-throughput analysis and so on. [8][9][10] At present, a variety of microuidic chips have been developed to detect tumor markers including CEA, 11,12 PSA, [13][14][15] AFP, 16,17 EGFR, 18 CA125 (ref. 19 and 20) and so on.…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of a microfluidic chip to detect tumor markers

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Design and fabrication of a microfluidic chip to detect tumor markers

et al. 2020

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“…Utilizing the advances in microfluidics a practical device concept was envisioned as a Lab-on-Chip (LoC) [41]. A LoC is a device consisting of a network of microfluidic channels and microcells capable of transferring fluids to perform several functions such as chemical analysis, reactions, and sorting.…”

Section: Microfluidics and Lab-on-chipmentioning

confidence: 99%

“…A LoC is a device consisting of a network of microfluidic channels and microcells capable of transferring fluids to perform several functions such as chemical analysis, reactions, and sorting. Typical applications were in the area of medical sciences where small amounts of samples were needed to perform tests and diagnoses [41]. While the dominant application area of LoCs remains efficient medical diagnoses, advances in manufacturing capability using Integrated Circuit (IC) fabrication methodologies or 3D printing their applicability is expanding into sensing and processing more widely.…”

Section: Microfluidics and Lab-on-chipmentioning

confidence: 99%

Neural network execution using nicked DNA and microfluidics

Solanki,

Griffin,

Sutradhar

et al. 2023

PLoS ONE

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DNA has been discussed as a potential medium for data storage. Potentially it could be denser, could consume less energy, and could be more durable than conventional storage media such as hard drives, solid-state storage, and optical media. However, performing computations on the data stored in DNA is a largely unexplored challenge. This paper proposes an integrated circuit (IC) based on microfluidics that can perform complex operations such as artificial neural network (ANN) computation on data stored in DNA. We envision such a system to be suitable for highly dense, throughput-demanding bio-compatible applications such as an intelligent Organ-on-Chip or other biomedical applications that may not be latency-critical. It computes entirely in the molecular domain without converting data to electrical form, making it a form of in-memory computing on DNA. The computation is achieved by topologically modifying DNA strands through the use of enzymes called nickases. A novel scheme is proposed for representing data stochastically through the concentration of the DNA molecules that are nicked at specific sites. The paper provides details of the biochemical design, as well as the design, layout, and operation of the microfluidics device. Benchmarks are reported on the performance of neural network computation.

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“…This enabled replicating the liver microenvironment and showed excellent potential for early personalized drug screening. Farazmand et al [ 111 ] used SLA of transparent resin to fabricate a modular microfluidic and electrical integration lab on a prostate cancer diagnosis chip. The authors were able to achieve a volumetric flow rate of 33 mL min −1 without leakage using a 3 μm‐wide release trench.…”

Section: Applicationsmentioning

confidence: 99%

Microadditive Manufacturing Technologies of 3D Microelectromechanical Systems

2021

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Conventional microfabrication processes have been well established, but their capabilities are generally limited simple and 2D extruded geometries. Additive manufacturing allows the ability to manufacture true 3D complex geometries, rapid design for manufacturing, mass customization, materials savings, and high precision, which have triggered the increased interest in manufacturing microelectromechanical systems (MEMS). Herein, MEMS manufacturing's recent advancements, including both conventional and additive manufacturing technologies, their working principles, and practical capabilities are consolidated. The use of additive manufacturing in several MEMS areas such as in microelectronics, circuitry, microfluidics, lab on a chip, packaging, and structural MEMS is also discussed in detail. Furthermore, the potentials and limitations of additive manufacturing are investigated with regard to the MEMS requirements. Finally, the technology outlook and improvements are discussed. This study shows that additive manufacturing offers a promising future for the fabrication of MEMS, especially using high‐resolution techniques such as microstereolithography, materials jetting, and materials extrusion. In contrast, current challenges such as materials requirements, equipment innovation, fabricating of in vivo devices for biomedical applications, inherited defects and poor surface finish, adhesion to substrates, and productivity are areas that require further study to increase the uptake by the MEMS community.

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Design and Development of a Disposable Lab-on-a-Chip for Prostate Cancer Detection

Cited by 6 publications

References 18 publications

Design and fabrication of a microfluidic chip to detect tumor markers

Design and fabrication of a microfluidic chip to detect tumor markers

Neural network execution using nicked DNA and microfluidics

Microadditive Manufacturing Technologies of 3D Microelectromechanical Systems

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