This article describes the design and development of a low-cost, portable monitoring system for indoor environment quality (IEQ). IEQ is a holistic concept that encompasses elements of indoor air quality (IAQ), indoor lighting quality (ILQ), acoustic comfort, and thermal comfort (temperature and relative humidity). The unit is intended for the monitoring of temperature, humidity, PM2.5, PM10, total VOCs (×3), CO2, CO, illuminance, and sound levels. Experiments were conducted in various environments, including a typical indoor working environment and outdoor pollution, to evaluate the unit’s potential to monitor IEQ parameters. The developed system was successfully able to monitor parameter variations, based on specific events. A custom IEQ index was devised to rate the parameter readings with a simple scoring system to calculate an overall IEQ percentage. The advantages of the proposed system, with respect to commercial units, is associated with better customisation and flexibility to implement a variety of low-cost sensors. Moreover, low-cost sensor modules reduce the overall cost to provide a comprehensive, portable, and real-time monitoring solution. This development facilities researchers and interested enthusiasts to become engaged and proactive in participating in the study, management, and improvement of IEQ.