Design and Development of a Three-Dimensional Printing High-Throughput Melt Electrowriting Technology Platform

Wunner, Felix M.; Eggert, Sebastian; Maartens, Joachim; Bas, Onur; Dalton, Paul D.; Hutmacher, Dietmar W.

doi:10.1089/3dp.2017.0149

Cited by 38 publications

(29 citation statements)

References 43 publications

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“…[8]. Polymer melts have been elecrospun in melt electro-writing (MEW) to create organized fibrous scaffolds, but they are incompatible with heat sensitive polymers like collagen [13][14][15][16][17][18]. Additionally, varying polymer solutions and custom equipment make it is necessary to re-optimize methods across laboratories.…”

Section: Introductionmentioning

confidence: 99%

A Parameter Study for 3D-Printing Organized Nanofibrous Collagen Scaffolds Using Direct-Write Electrospinning

Alexander

Johnson²,

Williams

et al. 2019

Materials

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Collagen-based scaffolds are gaining more prominence in the field of tissue engineering. However, readily available collagen scaffolds either lack the rigid structure (hydrogels) and/or the organization (biopapers) seen in many organ tissues, such as the cornea and meniscus. Direct-write electrospinning is a promising potential additive manufacturing technique for constructing highly ordered fibrous scaffolds for tissue engineering and foundational studies in cellular behavior, but requires specific process parameters (voltage, relative humidity, solvent) in order to produce organized structures depending on the polymer chosen. To date, no work has been done to optimize direct-write electrospinning parameters for use with pure collagen. In this work, a custom electrospinning 3D printer was constructed to derive optimal direct write electrospinning parameters (voltage, relative humidity and acetic acid concentrations) for pure collagen. A LabVIEW program was built to automate control of the print stage. Relative humidity and electrospinning current were monitored in real-time to determine the impact on fiber morphology. Fiber orientation was analyzed via a newly defined parameter (spin quality ratio (SQR)). Finally, tensile tests were performed on electrospun fibrous mats as a proof of concept.

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Section: Introductionmentioning

confidence: 99%

A Parameter Study for 3D-Printing Organized Nanofibrous Collagen Scaffolds Using Direct-Write Electrospinning

Alexander

Johnson²,

Williams

et al. 2019

Materials

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Section: Thermal Requirementsmentioning

confidence: 99%

“…MEW, therefore, was used to produce scaffolds for researchers consisting of ordered fibers with micrometer size in diameter. However, scale-up productions, which are necessary to effectively translate to industrial applications, are only commencing [44] and require uniform jet formation across different nozzles. Figure 8I-L shows a MEW system including eight simultaneously extruding printheads, which enabled to fabricate large-scale structures based on printing parameters given from a single-head system.…”

Section: Scale-up Systemsmentioning

confidence: 99%

Polymers for Melt Electrowriting

Kade

Dalton

2020

Adv Healthcare Materials

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161

155

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Melt electrowriting (MEW) is an emerging high‐resolution additive manufacturing technique based on the electrohydrodynamic processing of polymers. MEW is predominantly used to fabricate scaffolds for biomedical applications, where the microscale fiber positioning has substantial implications in its macroscopic mechanical properties. This review gives an update on the increasing number of polymers processed via MEW and different commercial sources of the gold standard poly(ε‐caprolactone) (PCL). A description of MEW‐processed polymers beyond PCL is introduced, including blends and coated fibers to provide specific advantages in biomedical applications. Furthermore, a perspective on printer designs and developments is highlighted, to keep expanding the variety of processable polymers for MEW.

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“…By keeping the flow rate small, and therefore the effect of gravity, the same group was able to upscale the melt electrospinning process. With an innovative apparatus design, they were able to horizontally spin on both sides of the collector and produce large scaffolds [ 67 ]. Therefore, they acknowledge that gravity can affect the electrospinning, but it is only an issue when accompanied by high flow rates.…”

Section: State Of the Art—impact Of Apparatus Orientation In Electmentioning

confidence: 99%

Impact of Apparatus Orientation and Gravity in Electrospinning—A Review of Empirical Evidence

2020

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Electrospinning is a versatile fibre fabrication method with applications from textile to tissue engineering. Despite the appearance that the influencing parameters of electrospinning are fully understood, the effect of setup orientation has not been thoroughly investigated. With current burgeoning interest in modified and specialised electrospinning apparatus, it is timely to review the impact of this seldom-considered parameter. Apparatus configuration plays a major role in the morphology of the final product. The primary difference between spinning setups is the degree to which the electrical force and gravitational force contribute. Since gravity is much lower in magnitude when compared with the electrostatic force, it is thought to have no significant effect on the spinning process. But the shape of the Taylor cone, jet trajectory, fibre diameter, fibre diameter distribution, and overall spinning efficiency are all influenced by it. In this review paper, we discuss all these developments and more. Furthermore, because many research groups build their own electrospinning apparatus, it would be prudent to consider this aspect as particular orientations are more suitable for certain applications.

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Design and Development of a Three-Dimensional Printing High-Throughput Melt Electrowriting Technology Platform

Cited by 38 publications

References 43 publications

A Parameter Study for 3D-Printing Organized Nanofibrous Collagen Scaffolds Using Direct-Write Electrospinning

A Parameter Study for 3D-Printing Organized Nanofibrous Collagen Scaffolds Using Direct-Write Electrospinning

Polymers for Melt Electrowriting

Impact of Apparatus Orientation and Gravity in Electrospinning—A Review of Empirical Evidence

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