Applied Microbiology and Bioengineering 2019
DOI: 10.1016/b978-0-12-815407-6.00009-5
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Design and Development of Antibiotic Fermentation Using Different Processing Strategies: Challenges and Perspectives

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Cited by 4 publications
(3 citation statements)
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“…Alteration of the configuration of an existing antimicrobial is a different effective strategy to determine the β-lactamase enzyme working. More recent cephalosporins have recently been changed with the evacuation of the aminoadipoyl side chain to produce 7-aminocephalosporanic acid and to make it 100 times more successful (to make it effective) than the older age cephalosporin [ 15 , 16 , 17 ] ( Table 1 ).…”
Section: Antibacterial-resistance Mechanismmentioning
confidence: 99%
“…Alteration of the configuration of an existing antimicrobial is a different effective strategy to determine the β-lactamase enzyme working. More recent cephalosporins have recently been changed with the evacuation of the aminoadipoyl side chain to produce 7-aminocephalosporanic acid and to make it 100 times more successful (to make it effective) than the older age cephalosporin [ 15 , 16 , 17 ] ( Table 1 ).…”
Section: Antibacterial-resistance Mechanismmentioning
confidence: 99%
“…The total synthesis of antibiotics and other bioactive natural products, according to Kuniaki Tatsuta, one of the pioneers in this field, "is a display of beauty, achieving a status of 'art' in organic chemistry" [35]. Therefore, the main source for obtaining the discovered pharmaceutically significant SMs was the fermentation of microbial strains, since total synthesis proved too complicated or too expensive [36,37]. Along with this, for the production of some antibiotics, schemes of multi-stage chemical synthesis (or total synthesis) were developed, leading to a yield comparable in economic costs [38].…”
Section: Introductionmentioning
confidence: 99%
“…One of the main methods of combating microbial resistance, since the end of the Golden Era of antibiotics, is the modification of compounds that have become inactive, which makes it possible to overcome resistance [36]. For example, in the UK in 1961, the so-called methicillin-resistant Staphylococcus aureus (MRSA), resistant both directly to methicillin and to other beta-lactam antibiotics, including penicillins, cephalosporins, and carbapenems, was first recorded.…”
Section: Introductionmentioning
confidence: 99%