Design and Development of High Sensitive Surface Plasmon Resonance Biosensors for Glucose Detection

Abstract

A high-glucose diet may increase the probability of developing diabetes. Currently, instead of checking blood samples, bio-photonic sensors are used to detect glucose levels. Surface plasmon resonance (SPR) based sensors limit the need to prick patients' skin to draw blood samples whose glucose levels need to be determined. The motivation is to design a high-sensitivity and optimum resulting SPR biosensor for this purpose based on the Kretschmann configuration. In this configuration, multilayers are vertically stacked together to improve the optical and electronic properties of the proposed surface plasmon resonance sensor. MATLAB simulations were performed to determine the performance parameters, taking 633 nm as the operating wavelength. The CaF2/Ag/ZnSe/BP/SM-based structure has the highest sensitivity of 511 𝒅𝒆𝒈/𝑹𝑰𝑼 for the optimized thickness of the layers used in this structure. The performance parameters, including the sensitivity, full width at half maximum (FWHM), figure of merit (FoM), and detection accuracy (DA), were measured, and the results were compared to evaluate the findings. We strongly believe that employing such a structure would make glucose detection easier and more effective using SPR biosensors.