Design and Development of Novel Floating In Situ Gel of Amoxicillin for the Treatment of Peptic Ulcer Disease Caused by Helicobacter pylori

Treatment of H. pylori infection and gastric ulcer: Need for novel Pharmaceutical formulation

“…Chang et al prepared pH-sensitive hydrogel to deliver amoxicillin locally for H. pylori infection [ 158 ]. The floating in situ gel of amoxicillin developed by Patel et al for treating H. pylori -based gastric ulcers showed a drug release of 95.78% up to 12 h and a swelling index of 67.16%, and concluded that it is a convenient candidate for treating H. pylori -based gastric ulcers [ 159 ]. A pictorial representation is provided in Fig.…”