Design and development of temperature sensitive porous poly(NIPAAm‐AMPS) hydrogels for drug release of doxorubicin‐a cancer chemotherapy drug

Abstract

Temperature sensitive polymer network porous hydrogels were developed with N-Isopropylacrylamide (NIPAAm) and AMPS (2-acrylamido-2-methyl-1-propanesulfonicacid), as well as with sucrose as porogen by crosslinking with hydrophilic crosslinker N,N 1 -methylenebisacrylamide (MBA). The temperature responsive behaviour, the swelling/deswelling kinetics of the hydrogels were investigated. The structural and morphological characterizations of the developed hydrogels were obtained from FTIR spectroscopy and scanning electron microscopy (SEM). The increment in the lower critical solution temperature (LCST) of NIPAAm hydrogels can be done with the help of AMPS and it is confirmed with differential scanning calorimetry (DSC) as well as temperature dependent swelling curves. The model cancer chemotherapy drug Doxorubicin (Dox) was loaded into theses hydrogels and the release studies as well as the released profiles of the drug showed that more than 8-54% of the loaded drug was released in the first half-an-hour at a buffer solution of 7.4 and the rest of the drug was released slowly.

Hydrogels based on starch‐g‐poly(sodium‐2‐acrylamido‐2‐methyl‐1‐propane sulfonate‐co‐methacrylic acid) as controlled drug delivery systems

“…This results in an increase in the electrostatic repulsion between the ionized groups which enhances the swelling of the polymer. At higher levels of AMPSNa, more hydrophilic nature of the polymer matrix causes in increased swelling .…”

Novel-porous-Ag0nanocomposite hydrogels via green process for advanced antibacterial applications

“…The cause might be silver NPs highly stabilized in the porous hydrogels and their high performance as compared to nonporous hydrogels, which can concluded by swelling analyses, TGA, SEM, and TEM. Varaprasad et al 29 reported sucrose based porous hydrogels that absorbed a larger quantity of water, drug, and they release of drug quickly into the media in control manner. In present study, silver NPs that are developed contain porous hydrogels that have significant surfaces and charges, and these silver NPs interact more effectively with bacterial cell walls and progressively destroying the metabolic responses when compared to other hydrogels.…”

Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line

“…Positive controls were used for all the tested cells. Doxorubicin and etoposide are both used in cancer chemotherapy (Varaprasad et al, 2010;Chabner and Longo, 2011). Doxorubicin was selected as the main positive control; however, since the HCT-15 cell line was not very sensitive to this drug, presenting GI 50 values higher than the maximum tested (200 nM), etoposide was used as a positive control in this case.…”