Design and development of zero-order drug release gastroretentive floating tablets fabricated by 3D printing technology

Huanbutta, Kampanart; Sangnim, Tanikan

doi:10.1016/j.jddst.2019.06.004

Cited by 71 publications

(23 citation statements)

References 22 publications

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“…By varying these parameters, release profiles could be dominated by diffusion or swelling (or a combination), and the authors were capable of tuning until a zero-order release was achieved. Other literature similarly reports zero-order (or constant sustained) release [97,98]. These applications demonstrate the importance of small features in CAD designs for drug delivery.…”

Section: Controlled Releasementioning

confidence: 58%

Application of Micro-Scale 3D Printing in Pharmaceutics

Kjar

Huang

2019

Pharmaceutics

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3D printing, as one of the most rapidly-evolving fabrication technologies, has released a cascade of innovation in the last two decades. In the pharmaceutical field, the integration of 3D printing technology has offered unique advantages, especially at the micro-scale. When printed at a micro-scale, materials and devices can provide nuanced solutions to controlled release, minimally invasive delivery, high-precision targeting, biomimetic models for drug discovery and development, and future opportunities for personalized medicine. This review aims to cover the recent advances in this area. First, the 3D printing techniques are introduced with respect to the technical parameters and features that are uniquely related to each stage of pharmaceutical development. Then specific micro-sized pharmaceutical applications of 3D printing are summarized and grouped according to the provided benefits. Both advantages and challenges are discussed for each application. We believe that these technologies provide compelling future solutions for modern medicine, while challenges remain for scale-up and regulatory approval.

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Section: Controlled Releasementioning

confidence: 58%

Application of Micro-Scale 3D Printing in Pharmaceutics

Kjar

Huang

2019

Pharmaceutics

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“…References FDM 3D Printing [70,142] [ 55,72] [ 143,144] [75,145] [75,145] FDM and PAM 3D printing technologies rely on the extrusion of polymer melts and semi-solids through the nozzle. The major challenge here is to maintain a reproducible and consistent flow of materials throughout the printing process to make the printed dosage form flawless [53].…”

Section: Dosage Shape Size Complexitymentioning

confidence: 99%

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

et al. 2020

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Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion-based (both fused deposition modeling (FDM) and pressure-assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion-based 3D printing of pharmaceuticals and how their properties, as well as the behavior of polymer–active pharmaceutical ingredient (API) combinations, impact the printing process. Especially, understanding the rheology of the polymer and API–polymer mixtures is necessary for successful 3D printing of dosage forms or printed structures. This review has summarized a holistic materials–process perspective for polymers on extrusion-based 3D printing. The main focus herein will be both FDM and PAM 3D printing processes. It elaborates the discussion on the comparison of 3D printing with the traditional direct compression process, the necessity of rheology, and the characterization techniques required for the printed structure, drug, and excipients. The current technological challenges, regulatory aspects, and the direction toward which the technology is moving, especially for personalized pharmaceuticals and multi-drug printing, are also briefly discussed.

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“…In-vivo, X-beam CT investigations of optimized tablets indicated 8-h gastro maintenances in rodents represent by an animation arranged by a unique CT procedure. Huanbutta et al, (2019) 26 developed threedimensional printing advancements that are broadly utilized in clinical applications, mirroring the simplicity of customization and personalization. Henceforth, uses of 3D imprinting in pharmaceutical assembling may give assortment and unpredictability of pharmaceutical measurement frames that customary techniques don't.…”

Section: Fig 2: Drug Release Profiles Of the Formulations Used In Thmentioning

confidence: 99%

Untitled

2021

IJPSR

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Design and development of zero-order drug release gastroretentive floating tablets fabricated by 3D printing technology

Cited by 71 publications

References 22 publications

Application of Micro-Scale 3D Printing in Pharmaceutics

Application of Micro-Scale 3D Printing in Pharmaceutics

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

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