Design and Drug Release Properties of Time-Controlled Release Granule Containing Metominostrobin

Tashima, Shigeru; Shimada, Shinji; Nakajima, Yoshihiro; Ando, Iwao; Matsumoto, Keīichi; Takeda, Reiji; Shiraishi, Takeshi

doi:10.1584/jpestics.25.123

Cited by 4 publications

(3 citation statements)

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“…We developed a time-controlled release granule (TCRG) which was characterized by an active ingredient release with lag time. 3 It was found that the lag time could be optionally controlled by the amount of swelling agent and/or water insoluble membrane.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vehicle on Drug Release Profiles of Time-Controlled Release Granule Containing Metominostrobin

et al. 2000

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We examined the effect of talc as an vehicle on release profile of time-controlled release granule (TCRG). In this report, TCRG was prepared by coating a water insoluble polymer to the pre-coated granule which consists of a powder blend containing active ingredient, swelling agent and talc. The lag time of metominostrobin release from TCRG was prolonged with increase of talc, a hydrophobic vehicle. We discussed the mechanism in this phenomenon.

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Section: Introductionmentioning

confidence: 99%

Effect of Vehicle on Drug Release Profiles of Time-Controlled Release Granule Containing Metominostrobin

et al. 2000

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“…Controlled release (CR) is defined as: “the permeation-regulated transfer of an active ingredient (AI) from a reservoir to a targeted surface to maintain a predetermined concentration level for a specified period of time” 1 . CR has been applied in the agricultural, biomedical, food and pharmaceutical industries to deliver pesticides, herbicides, fertilizers, biomolecules, and drugs 2 – 5 . The development of CR devices for agriculture have culminated in a number of successful products.…”

Section: Introductionmentioning

confidence: 99%

Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol

Mun

Yameen

Edelbaum

et al. 2021

Sci Rep

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In recent years there has been a growing demand for the development of agrochemical controlled release (CR) technologies. In the present study, we aimed to create a novel agricultural CR device using two polymeric systems that have been predominantly employed in biomedical applications: beads of alginate hydrogel embedded with drug-bearing Polycaprolactone (PCL) microspheres. The combined device utilizes the advantages of each polymer type for biodegradation and controlled release of Paclobutrazol (PBZ), a common growth retardant in plants. Surface morphology of the alginate beads was characterized by scanning electron microscopy (SEM) and water immersion tests were performed for stability and controlled release measurements. Bioassays were performed both in accelerated laboratory conditions and in field conditions. The results showed a capability to control the size of PBZ-loaded PCL microspheres through modification of homogenization speed and emulsifier concentration. Enlargement of PCL microsphere size had an adverse effect on release of PBZ from the alginate device. The growth of oatmeal plants as a model system was affected by the controlled release of PBZ. The preliminary field experiment observed growth retardation during two consecutive rainy seasons, with results indicating a substantial benefit of the sustained growth inhibition through the controlled release formulation. The final product has the potential to be used as a carrier for different substances in the agrochemical industry.

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“…Therefore, we prepared a time-controlled release granule (TCRG) which was characterized by an active ingredi-ent, metominostrobin3, 4) to release with lag time. 5,6) In this report, we studied the effect of white carbon (hydrated silicon dioxide), which was contained in water insoluble polymer membrane of TCRG, on lag time and release rate of metominostrobin.…”

Section: Introductionmentioning

confidence: 99%

Effect of White Carbon Contained in Water Insoluble Polymer Membrane of Time-Controlled Release Granule on Release Profile of Metominostrobin

Tashima¹,

Shimada

Matsumoto

et al. 2000

J. Pestic. Sci.

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We investigated the effect of white carbon (hydrated silicon dioxide) contained in water insoluble polymer membrane on release profiles of metominostrobin from the time-controlled release granule (TCRG) containing metominostrobin. As the amount of white carbon increased, the lag time for release was shortened and the release rate became faster. Thus, the changes in both lag time and release rate were thought to be related to water permeability into the TCRG and tensile strength of the membrane induced by it. We also made a single regression model and a logistic model to predict release profile based on the amount of white carbon in TCRG using computer program NLIN procedure of SAS (Statistical Analysis Systems). As a result, the actual release profile fitted in a three parameter logistic model by non linear least-squares method.

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Design and Drug Release Properties of Time-Controlled Release Granule Containing Metominostrobin

Cited by 4 publications

References 0 publications

Effect of Vehicle on Drug Release Profiles of Time-Controlled Release Granule Containing Metominostrobin

Effect of Vehicle on Drug Release Profiles of Time-Controlled Release Granule Containing Metominostrobin

Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol

Effect of White Carbon Contained in Water Insoluble Polymer Membrane of Time-Controlled Release Granule on Release Profile of Metominostrobin

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