Design and evaluation of a novel dual-tuned resonator for spectroscopic imaging

Derby, Kevin; Tropp, James; Hawryszko, Christine

doi:10.1016/0022-2364(90)90043-9

Cited by 54 publications

(87 citation statements)

References 3 publications

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“…It is based on an earlier design (14) in which a halfHelmholtz and a low-pass birdcage resonator (in this instance with eight rungs) were mounted on a single cylinder so as to share a pair of legs. The present coil differs from that reported in Ref.…”

Section: Rf Coil and Scannermentioning

confidence: 99%

Hyperpolarized C‐13 spectroscopic imaging of the TRAMP mouse at 3T—Initial experience

Chen¹,

Albers²,

Cunningham³

et al. 2007

Magnetic Resonance in Med

193

286

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The transgenic adenocarcinoma of mouse prostate (TRAMP) mouse is a well-studied murine model of prostate cancer with histopathology and disease progression that mimic the human disease. To investigate differences in cellular bioenergetics between normal prostate epithelial cells and prostate tumor cells, in vivo MR spectroscopic (MRS) studies with non-proton nuclei, such as 13 C, in the TRAMP model would be extremely useful. The recent development of a method for retaining dynamic nuclear polarization (DNP) in solution permits high signal-tonoise ratio (SNR) 13 C MRI or MRSI data to be obtained following injection of a hyperpolarized 13 C agent. In this transgenic mouse study, this method was applied using a double spinecho (DSE) pulse sequence with a small-tip-angle excitation RF pulse, hyperbolic-secant refocusing pulses, and a flyback echo-planar readout trajectory for fast (10 -14 s) MRSI of 13 C pyruvate (pyr) and its metabolic products at 0.135 cm 3 nominal spatial resolution. The transgenic adenocarcinoma of mouse prostate (TRAMP) mouse is an established and well-studied murine model of prostate cancer (1,2). The histopathology of TRAMP mouse cancer tissue mimics that of human disease. TRAMP mice develop spontaneous progressive disease that begins with prostatic intraepithelial neoplasia (PIN) and then advances to frank carcinoma lesions in the prostatic lobes. The cancer also frequently metastasizes in this model to the lymph nodes (LN) and lungs, and, to a lesser extent, to the kidneys, adrenal glands, liver, and bone (2). The TRAMP model is being used in numerous laboratories to identify the molecular mechanisms associated with the initiation and progression of metastatic prostate cancer. Currently, almost all TRAMP studies use histopathology as the only parameter to evaluate the progression of the disease as well as the efficacy of the treatment agent being tested. Although this parameter is very useful and informative, the mouse has to be killed. Having a noninvasive, in vivo method would be valuable for following disease progression and treatment response in the same animal. TRAMP mice also serve as a good model system for testing new methods to characterize human prostate cancers.Combined proton MRI and MR spectroscopic imaging (MRSI) exams have become routine clinical procedures for characterizing prostate cancer in humans (3-6). In particular, proton MRSI allows identification of changes associated with prostate cancer biomarkers, such as an increase in choline and a reduction in citrate. Single-voxel proton MRS data have been demonstrated in the TRAMP model (7), but this required a 7T animal MR system and an extremely long acquisition time (ϳ2 hr for a single-voxel spectrum). Studying cellular bioenergetics in the TRAMP mouse would also benefit from in vivo MRS studies with non-proton nuclei, such as 13 C, but due to the low natural abundance of 13 C and its low sensitivity compared to the proton, the signal-to-noise ratio (SNR) is prohibitively low in small animals. With the recent development ...

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Section: Rf Coil and Scannermentioning

confidence: 99%

Hyperpolarized C‐13 spectroscopic imaging of the TRAMP mouse at 3T—Initial experience

Chen¹,

Albers²,

Cunningham³

et al. 2007

Magnetic Resonance in Med

193

286

View full text Add to dashboard Cite

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“…Rat hind paws were positioned in a custombuilt dual-tuned 1 H- 13 C quadrature birdcage radiofrequency coil (50 mm inner diameter, 70 mm long) designed for both signal excitation and reception. The coil was based on a previously published design ( 19 ), but with a second half-Helmholtz unit added to provide quadrature operation in the proton mode.…”

Section: Mr Hardware and Radiofrequency Coilsmentioning

confidence: 99%

Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

MacKenzie¹,

Yen²,

Mayer³

et al. 2011

Radiology

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Purpose:To examine the feasibility of using magnetic resonance (MR) spectroscopy with hyperpolarized carbon 13 ( 13 C)-labeled pyruvate to detect infl ammation. Materials and Methods:The animal care and use committee approved all work with animals. Arthritis was induced in the right hind paw of six rats; the left hind paw served as an internal control. The lactate dehydrogenase-catalyzed conversion of pyruvate to lactate was measured in infl amed and control paws by using 13 C MR spectroscopy. Clinical and histologic data were obtained to confi rm the presence and severity of arthritis. Hyperpolarized 13 C-pyruvate was intravenously injected into the rats before simultaneous imaging of both paws with 13 C MR spectroscopy. The Wilcoxon signed rank test was used to test for differences in metabolites between the control and arthritic paws.

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“…A syringe filled with [1-13 C]lactate at thermal equilibrium polarization, as external signal reference, was also placed in the FOV. Experiments were performed on a Signa HDx 3 T MR imaging system (GE Healthcare) using a (diameter, 78 mm) dual-tuned 1 H/ 13 C radiofrequency coil (27) and whole-body gradient coil with a 23 mT/m maximum gradient amplitude and 77 T/m/s slew rate. Tumors were localized using standard 1 H imaging with 2-dimensional gradient echo acquisition in the axial, sagittal, and coronal orientations.…”

Section: Hyperpolarizationmentioning

confidence: 99%

Multimodal Assessment of In Vivo Metabolism with Hyperpolarized [1-¹³C]MR Spectroscopy and ¹⁸F-FDG PET Imaging in Hepatocellular Carcinoma Tumor–Bearing Rats

et al. 2013

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Abnormalities of tumor metabolism can be exploited for molecular imaging. PET imaging of 18 F-FDG is a well-established method using the avid glucose uptake of tumor cells. 13 C MR spectroscopic imaging (MRSI) of hyperpolarized [1-13 C]pyruvate and its metabolites, meanwhile, represents a new method to study energy metabolism by visualizing, for example, the augmented lactate dehydrogenase activity in tumor cells. Because of rapid signal loss, this method underlies strict temporal limitations, and the acquisition of data-encoding spatial, temporal, and spectral information within this time frame-is challenging. The object of our study was to compare spectroscopic images with 18 F-FDG PET images for visualizing tumor metabolism in a rat model. Methods: 13 C MRSI with IDEAL (Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation) chemical shift imaging in combination with single-shot spiral acquisition was used to obtain dynamic data from 23 rats bearing a subcutaneous hepatocellular carcinoma and from reference regions of the same animals. Static and dynamic analysis of 18 F-FDG PET images of the same animals was performed. The data were analyzed qualitatively (visual assessment) and quantitatively (magnitude and dynamics of 18 F-FDG uptake, 13 Significantly less pyruvate reached the tumors than the gastrointestinal tract, but in tumors a significantly higher amount of pyruvate was converted to lactate and alanine within seconds after intravenous administration. Conclusion: This study reveals that PET and 13 C MRSI can be used to visualize increased glycolytic flux in malignant tissue. The combination of signals will allow the quantitative dissection of substrate metabolism, with respect to uptake and downstream metabolic pathways. Although hyperpolarized [1-13 C]pyruvate increases the sensitivity of MR imaging, signal-to-noise ratio constraints still apply for spatially and temporally resolved 13 C MRSI, emphasizing the need for further MR methodologic development. These first imaging data suggest the feasibility of 13 C MRSI for future clinical use.

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Design and evaluation of a novel dual-tuned resonator for spectroscopic imaging

Cited by 54 publications

References 3 publications

Hyperpolarized C‐13 spectroscopic imaging of the TRAMP mouse at 3T—Initial experience

Hyperpolarized C‐13 spectroscopic imaging of the TRAMP mouse at 3T—Initial experience

Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

Multimodal Assessment of In Vivo Metabolism with Hyperpolarized [1-¹³C]MR Spectroscopy and ¹⁸F-FDG PET Imaging in Hepatocellular Carcinoma Tumor–Bearing Rats

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Design and evaluation of a novel dual-tuned resonator for spectroscopic imaging

Cited by 54 publications

References 3 publications

Hyperpolarized C‐13 spectroscopic imaging of the TRAMP mouse at 3T—Initial experience

Hyperpolarized C‐13 spectroscopic imaging of the TRAMP mouse at 3T—Initial experience

Detection of Inflammatory Arthritis by Using Hyperpolarized13C-Pyruvate with MR Imaging and Spectroscopy

Multimodal Assessment of In Vivo Metabolism with Hyperpolarized [1-13C]MR Spectroscopy and 18F-FDG PET Imaging in Hepatocellular Carcinoma Tumor–Bearing Rats

Contact Info

Product

Resources

About

Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

Multimodal Assessment of In Vivo Metabolism with Hyperpolarized [1-¹³C]MR Spectroscopy and ¹⁸F-FDG PET Imaging in Hepatocellular Carcinoma Tumor–Bearing Rats