Design and evaluation of buccal films as paediatric dosage form for transmucosal delivery of ondansetron

Trastullo, Ramona; Abruzzo, Angela; Saladini, Bruno; Gallucci, Maria Caterina; Cerchiara, Teresa; Luppi, Barbara; Bigucci, Federica

doi:10.1016/j.ejpb.2016.05.026

Cited by 54 publications

(19 citation statements)

References 26 publications

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“…It seems that the higher viscosity of the CGH solutions lower the permeation rates of CGH. This results are considered to be in agreement with the previous findings that polymeric solutions limited the diffusion of drugs . Figure (a) shows that, at a given CGH amount, the cumulative percentage of permeated CGH is lower in polymer solutions (P1–P5) than in water solution (S2).…”

Section: Resultssupporting

confidence: 92%

Viscosity Effects of Hydrophilic Polymers on Transport of Collagen Hydrolysate Across Reconstructed Human Buccal Tissue

Koo

Lee

Yeo

et al. 2020

Bulletin Korean Chem Soc

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Herein we investigate the influence of hydrophilic polymers on the buccal permeability of collagen hydrolysate (CGH) by performing in vitro buccal permeation test and viscosity measurements. After we demonstrated that CGH (2000–3000 Da) could be delivered across the reconstructed human buccal tissue as evaluated by hydroxyproline assay, the effects of different hydrophilic polymers, varying amounts of CGH, and hydration methods were examined to elucidate the relationship with buccal permeation behavior of CGH. The percentage of CGH permeated was found to be highest in HPMC E5 solution and greater when the viscosity of test solutions was low. Using commercially obtained CGH‐loaded buccal films, the films under higher hydration condition exhibited greater CGH permeation. This study demonstrates that CGH can be delivered via the human buccal tissue and viscosity of the solution significantly affects the CGH permeation. These findings are valuable for designing hydrophilic polymer‐based buccal film formulations for peptides like CGH.

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Section: Resultssupporting

confidence: 92%

Viscosity Effects of Hydrophilic Polymers on Transport of Collagen Hydrolysate Across Reconstructed Human Buccal Tissue

Koo

Lee

Yeo

et al. 2020

Bulletin Korean Chem Soc

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“…The gel remained in situ until 20 ± 1 or 24 ± 2 h when the loaded face of the film was exposed to the medium or attached to the mucosa, respectively. These results were in agreement with our previous published data [39], where a similar residence time was observed for HPMC-based films. Moreover, the presence of sugars in L. brevis CD2 peptidoglycan can contribute to improving the mucoadhesive properties and consequently to increasing the residence time [37].…”

Section: In Vitro Residence Time and Mucoadhesive Ability Of Buccal Fsupporting

confidence: 94%

“…Great mucoadhesion and extended release represent key properties in order to achieve local persistence of probiotics and their metabolites in the buccal cavity. In this study, HPMC-loaded films showed good mucoadhesive ability as a consequence of interpenetration and entanglement of polymer chains into the mucus layer, as well as the hydrogen bonds established between the polymer hydrophilic groups and the hydrophilic groups of mucus [39,42]. The highest residence time and mucoadhesive ability were obtained when the loaded face of the film was attached to the mucosa: the presence of sugars in the L. brevis CD2 peptidoglycan layer may encourage the formation of other hydrogen and van der Waals bonds, thus increasing the film residence time on porcine mucosa and improving the mucoadhesive properties [37].…”

Section: Discussionmentioning

confidence: 72%

Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis

et al. 2020

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The aim of this work was to prepare mucoadhesive buccal films for local release of Lactobacillus brevis CD2, which shows interesting anti-inflammatory properties due to its high levels of arginine deiminase. Hydroxypropylmethylcellulose-based films were prepared by means of a modified casting method, which allowed L. brevis CD2 loading on one side of the film, before its complete drying. Three batches of films were prepared, stored at +2-8 • C and +23-25 • C for 48 weeks and characterized in terms of physico-chemical and functional properties. For each batch, the L. brevis viable count and arginine deiminase activity were evaluated at different time points in order to assess functional property maintenance over time. Moreover, the mucoadhesive properties and ability of the films to release L. brevis CD2 were evaluated. A good survival of L. brevis CD2 was observed, particularly at the storage temperature of +2-8 • C, while the activity of arginine deiminase was maintained at both temperature values. Films showed good mucoadhesive properties and guaranteed a prolonged release of viable lactobacilli, which can be directed towards the whole buccal cavity or specific mucosa lesions. In conclusion, the proposed preparative method can be successfully employed for the production of buccal films able to release viable L. brevis CD2 cells that maintain the anti-inflammatory enzymatic activity.

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“…It has also been reported that the gelling power of κ-and ιcarrageenans impart excellent film-forming properties (Park et al, 2001). Even though the interest in pharmaceutical films has increased according to publications in recent years (Chonkar et al, 2016;Krampe et al, 2016;Montenegro-Nicolini and Morales, 2017;Morales and Brayden, 2017;Park et al, 2001;Real et al, 2013;Trastullo et al, 2016;Woertz and Kleinebudde, 2015), more research is needed in order to overcome potential limitations and increase general patient acceptance (Sievens-Figueroa et al, 2012). Regarding the films, numerous systems have been described in literature where the active ingredient have been dissolved or dispersed within the polymeric material (El-Kamel et al, 2007;Gallagher and Corrigan, 2000;Kolakovic et al, 2012;Perugini et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of drug incorporation technique and polymer combination on the performance of biopolymeric antifungal buccal films

Tejada

Lamas

Svetaz

et al. 2018

International Journal of Pharmaceutics

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Numerous films with a dissolved or dispersed active principle within a polymeric matrix have been described in literature. However, the incorporation of solid crystals into the films may influence several relevant properties. Additionally, it has been reported that different polymeric matrices lead to films presenting a different performance. The aim of this work was to evaluate the effect of the combination of chitosan with carrageenan (κ-, λ-, and ι-) as matrices, and of the miconazole nitrate incorporation method, on the films behavior. Mechanical properties, drug release and antifungal activity were evaluated. The state of the drug in the films was analyzed by different techniques. Films showed a homogeneous surface and a thermal protective effect on the drug. The combination of chitosan and λ-carrageenan leads to films with the highest values of tensile and mucoadhesive strength. Films with solubilized drug displayed slightly higher elongation at break, tensile and mucoadhesive strength and faster drug release than those with suspended miconazole nitrate. However, no differences were found regarding the antifungal activity of the different formulations including time-to-kill curves.

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Design and evaluation of buccal films as paediatric dosage form for transmucosal delivery of ondansetron

Cited by 54 publications

References 26 publications

Viscosity Effects of Hydrophilic Polymers on Transport of Collagen Hydrolysate Across Reconstructed Human Buccal Tissue

Viscosity Effects of Hydrophilic Polymers on Transport of Collagen Hydrolysate Across Reconstructed Human Buccal Tissue

Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis

Effect of drug incorporation technique and polymer combination on the performance of biopolymeric antifungal buccal films

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