Design and evaluation of molecular organogel based on folic acid as a potential green drug carrier for oral route

Mohamed, Masar Basim Mohsin; Dahabiyeh, Lina A.; Sahib, Mohanad Naji

doi:10.1080/03639045.2022.2118316

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Interestingly, the reductive acetylation of 2‐hydroxynitrobenzene gave N ‐(5‐acetyl‐2‐hydroxyphenyl) acetamide, owing to the acid catalyzed Fries rearrangement of the proposed reductive acetylation product, that is, 2‐acetamidophenyl‐acetate (Table 2, Entry 12) 40 . It was observed that substrates consisting of substituents that can be reduced by NaBH 4 gets completely reduced in the presence of our catalyst ( 1g , 1h , and 1j ) (Scheme 4).…”

Section: Catalytic Application Of Pd‐l4 Npsmentioning

confidence: 99%

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Gupta,

Srivastava,

V.S. Ranganath

2023

Applied Organom Chemis

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A series of Gemini surfactants (GSs) were prepared by reacting alkyl bromides with N,N,N′,N′‐tetramethyl ethylenediamine. Various alkyl bromides used in for the preparation of GSs are 1,3‐dibromo ethane, 1,3‐dibromoethane, 1‐Bromohexane, 1‐Bromooctane, 1‐Bromooctadecane and 1‐Bromooctadodecane. Different solvents and temperatures were investigated for the formation of gels of prepared GSs. Among all, 1‐Bromooctane, 1‐Bromooctadecane‐derived GSs formed organogels. Thus, synthesized long‐chain organogels have been used to stabilize Pd NPs. The Pd NPs formation initially confirmed through Ultraviolet‐visible, Scanning Electron Microscopy, and Atomic Force Micrograph studies. Later Fourier Tansform Infra Red, Thermo Gravimetric Analysis, and Zeta potential studies were also carried out to understand their properties extensively. The Pd NPs stabilized by GSs have been identified as a potential catalyst in the reductive N‐acetylation of nitroaromatics at room temperature. The N‐acetylated products were obtained in good yields in an aqueous medium. In addition, the potentiality of our catalyst has been also evaluated in the reduction of nitroaromatics in an aqueous medium, which is a green protocol. Further, the semi‐empirical geometry optimizations of active GS gel confirmed the dihedral angle of 59° in between the two octyl moieties calculated from computational studies. The rheological properties such as amplitude sweeping, viscosity shear profile of the gel have also been studied.

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Section: Catalytic Application Of Pd‐l4 Npsmentioning

confidence: 99%

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Gupta,

Srivastava,

V.S. Ranganath

2023

Applied Organom Chemis

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Tailoring and Optimization of Nifedipine Controlled Release Organogel via Quality by Design Approach

Dave,

Kariya,

Dudhat

2024

J Pharm Innov

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Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration

Razaq,

Masar Basim Mohsin Mohamed,

Lina A. Dahabiyeh

2024

AJPS

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Background: Curcumin (CUR) and its derivatives have shown a wide variety of biological activities, such as anti-oxidant, anti-inflammatory, anti-tumor, antimicrobial and antiparasitic effects as well as for the treatment of skin diseases. Due to its physico-chemical limitations such as low aqueous solubility and low bioavailability, we developed curcumin organogel as a topical delivery system to overcome those limitations. The12-hydroxystearic acid (12-HSA) is well known as a low-molecular-weight organogelators (LMOGs) capable of gelling an organic liquid phase. Different concentrations of (12-HSA) in triacetin with 50 mg CUR were gelled and applied for various examinations: tabletop rheology, oil binding capacity, pH measurement, spreadability, in vitro drug release, antibacterial activity and oscillatory rheology studies. The results revealed that the organogels transition temperatures from solid to liquid were greater than the normal body temperature, this helped the organogels keep their shape; they had good spreadability,and the organogels pH levels were within the safe range for the skin . In vitro release data showed that 4% 12HSA+5%CUR +TA (4TA) gave us 100% release after 6 hours. The selected 4TA illustrated good viscoelastic properties in the amplitude sweep test and a frequency-independent as seen in the frequency sweep test. CUR has good antibacterial action against Staphylococcus aureus; Streptococcus pyrogen, Proteus mirabilis, and Escherichia coli, which prevail at the site of wound injury as this pointed out that 4TA organogel can be used for topical wound healing.

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Design and evaluation of molecular organogel based on folic acid as a potential green drug carrier for oral route

Cited by 3 publications

References 44 publications

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Tailoring and Optimization of Nifedipine Controlled Release Organogel via Quality by Design Approach

Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration

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