Design and Evaluation of Natural Mucilage Microspheres of Sesamol for Gastroretentive Drug Delivery

Abstract

The mucilages are polysaccharide obtained from various seeds. The mucilage have good swelling and water holding capacity. The mucoadhesive potential of mucilage is recently explored area. Thus, present study aimed to formulate Mimosa pudica mucilage based microspheres for gastroretentive delivery of sesamol. The drug loaded microspheres were formulated using ionic gelation method and evaluated for physicochemical properties, mucoadhesive potential, swelling index and in vitro drug release study. The microspheres showed good particle size and drug entrapment. The good swelling ability, mucoadhesive potential coupled with sustained drug release could be promising for gastroretentive drug delivery. Thus, natural mucilage could be alternative carrier for preparation of mucoadhesive microspheres of drug.