Design and Evaluation of pH-Dependent Nanosystems Based on Cellulose Acetate Phthalate, Nanoparticles Loaded with Chlorhexidine for Periodontal Treatment

Vidal-Romero, Gustavo; Zambrano-Zaragoza, María L.; Martínez-Acevedo, Lizbeth; Leyva-Gómez, Gerardo; Mendoza-Elvira, Susana; Quintanar‐Guerrero, David

doi:10.3390/pharmaceutics11110604

Cited by 24 publications

(16 citation statements)

References 53 publications

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“…Vidal-Romero and colleagues synthesised o/w NCs that were applied as pills that melt in the mouth, for treating patients diagnosed with periodontitis. According to their results, their o/w NCs loaded with chlorhexidine significantly reduced the oral plaque in comparison to chlorhexidine mouthwash [11].…”

Section: Introductionmentioning

confidence: 99%

Characterisation of the Interaction among Oil-In-Water Nanocapsules and Mucin

et al. 2020

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Mucins are glycoproteins present in all mucosal surfaces and in secretions such as saliva. Mucins are involved in the mucoadhesion of nanodevices carrying bioactive molecules to their target sites in vivo. Oil-in-water nanocapsules (NCs) have been synthesised for carrying N,N′-(di-m-methylphenyl)urea (DMTU), a quorum-sensing inhibitor, to the oral cavity. DMTU-loaded NCs constitute an alternative for the treatment of plaque (bacterial biofilm). In this work, the stability of the NCs after their interaction with mucin is analysed. Mucin type III from Sigma-Aldrich has been used as the mucin model. Mucin and NCs were characterised by the multi-detection asymmetrical flow field-flow fractionation technique (AF4). Dynamic light scattering (DLS) and ζ-potential analyses were carried out to characterise the interaction between mucin and NCs. According to the results, loading DMTU changes the conformation of the NC. It was also found that the synergistic interaction between mucin and NCs was favoured within a specific range of the mucin:NC ratio within the first 24 h. Studies on the release of DMTU in vitro and the microbial activity of such NCs are ongoing in our lab.

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Section: Introductionmentioning

confidence: 99%

Characterisation of the Interaction among Oil-In-Water Nanocapsules and Mucin

et al. 2020

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“…At pH lower than 3–3.6, the scaffolds showed a positive ζ, while a negative surface ζ was present in all the scaffolds when pH was higher than 3–3.6. This means that scaffolds should be negatively charged in the periodontal pocket environment, which has a pH ranging from 5 to 7 [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Electrospun Scaffolds in Periodontal Wound Healing

Budai-Szűcs,

Ruggeri,

Faccendini

et al. 2021

Polymers

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Periodontitis is a set of inflammatory conditions affecting the tissues surrounding the teeth predominantly sustained by bacterial infections. The aim of the work was the design and the development of scaffolds based on biopolymers to be inserted in the periodontal pocket to restore tissue integrity and to treat bacterial infections. Nanofibrous scaffolds were prepared by means of electrospinning. Gelatin was considered as base component and was associated to low and high molecular weight chitosans and alginate. The scaffolds were characterized by chemico–physical properties (morphology, solid state-FTIR and differential scanning calorimetry (DSC)-surface zeta potential and contact angle), and mechanical properties. Moreover, preclinical properties (cytocompatibility, fibroblast and osteoblast adhesion and proliferation and antimicrobial properties) were assessed. All the scaffolds were based on cylindrical and smooth nanofibers and preserved their nanofibrous structure upon hydration independently of their composition. They possessed a high degree of hydrophilicity and negative zeta potentials in a physiological environment, suitable surface properties to enhance cell adhesion and proliferation and to inhibit bacteria attachment. The scaffold based on gelatin and low molecular weight chitosan proved to be effective in vitro to support both fibroblasts and osteoblasts adhesion and proliferation and to impair the proliferation of Streptococcus mutans and Aggregatibacter actinomycetemcomitans, both pathogens involved in periodontitis.

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“…Quintanar-Guerrero and collaborators [ 48 ] prepared nanospheres and nanocapsules loaded with chlorhexidine using the emulsion-diffusion technique and cellulose acetate phthalate as pH-dependent polymeric material, in order to improve the treatment of periodontitis. These local drug delivery systems can infiltrate or be administered into the periodontal pocket.…”

Section: Smart Nanoparticles In Dentistrymentioning

confidence: 99%

The Benefits of Smart Nanoparticles in Dental Applications

Vasiliu¹,

Racoviţă²,

Gugoasa

et al. 2021

IJMS

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Dentistry, as a branch of medicine, has undergone continuous evolution over time. The scientific world has focused its attention on the development of new methods and materials with improved properties that meet the needs of patients. For this purpose, the replacement of so-called “passive” dental materials that do not interact with the oral environment with “smart/intelligent” materials that have the capability to change their shape, color, or size in response to an externally stimulus, such as the temperature, pH, light, moisture, stress, electric or magnetic fields, and chemical compounds, has received much attention in recent years. A strong trend in dental applications is to apply nanotechnology and smart nanomaterials such as nanoclays, nanofibers, nanocomposites, nanobubbles, nanocapsules, solid-lipid nanoparticles, nanospheres, metallic nanoparticles, nanotubes, and nanocrystals. Among the nanomaterials, the smart nanoparticles present several advantages compared to other materials, creating the possibility to use them in various dental applications, including preventive dentistry, endodontics, restoration, and periodontal diseases. This review is focused on the recent developments and dental applications (drug delivery systems and restoration materials) of smart nanoparticles.

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Design and Evaluation of pH-Dependent Nanosystems Based on Cellulose Acetate Phthalate, Nanoparticles Loaded with Chlorhexidine for Periodontal Treatment

Cited by 24 publications

References 53 publications

Characterisation of the Interaction among Oil-In-Water Nanocapsules and Mucin

Characterisation of the Interaction among Oil-In-Water Nanocapsules and Mucin

Electrospun Scaffolds in Periodontal Wound Healing

The Benefits of Smart Nanoparticles in Dental Applications

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