Design and Evaluation of Transdermal Films Containing Ketoprofen for the Treatment of Arthritis

Manjula, D.; Shabaraya, A R; Srikanth, P; Suma, R.

doi:10.22270/jddt.v2i4.240

Cited by 2 publications

(3 citation statements)

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“…The formulations were assessed for their physical appearance, drug content, pH, in vitro buoyancy, and drug release. 31,42,43…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Shabaraya,

T Ashwini,

Vineetha

2023

European Pharmaceutical Journal

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A revolutionary concept for achieving long-term medication release is the gastroretentive in situ gelling system. The goal of this research was to formulate and test a gastroretentive in situ gel for ketoprofen delivery to targeted site to increase the residence and delivery time. Ketoprofen gastroretentive in situ gels were synthesized using a cation-driven gelation approach using various combinations and concentrations of polymers such as gellan gum, sodium alginate, and hydroxypropyl methylcellulose (HPMC) K100M. Visual appearance, pH, viscosity, in vitro gelation, in vitro buoyancy, drug content, density measurement, gel strength measurement, water uptake, and in vitro drug release were all evaluated. The total floating time was more than 12 h, with a floating lag time of less than 2 min. The formulations showed pH ranging from 6.89 to 7.61 and drug content ranging from 82.01% to 95.53%. For 11 h, the percent cumulative drug release of formulations F5 and F14, which contained a greater concentration of polymer sodium alginate (1.5%) and a combination of gellan gum and HPMC K100M (0.175% and 0.2%), was 84.10% and 85.49%, respectively. In vitro dissolution experiments and stability investigations both revealed no significant changes in drug content. The findings revealed that the formulated in situ gels aided in extending gastric residence duration, allowing the drug to be released in the stomach.

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“…The formulations were assessed for their physical appearance, drug content, pH, in vitro buoyancy, and drug release. 31,42,43…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Shabaraya,

T Ashwini,

Vineetha

2023

European Pharmaceutical Journal

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“…The volumetric flask containing gel was shaken for a period of 2 h on mechanical shaker to get absolute solubility of drug. This solution was filtered and estimated spectrophotometrically at 272 nm using phosphate buffer pH 6.8 as blank [21].…”

Section: Drug Contentmentioning

confidence: 99%

“…The paw volume of all the animals, both control and test groups, was measured using plethysmograph at selected interval of time. Finally, the percentage reduction in edema volume was calculated and the activity of the formulation was statically analyzed by Student's "t" test [24].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Transdermal Delivery of an Effective Nonsteroidal Anti-Inflammatory Drugs for Pain Management in Arthritis

Manjula

Abhishek

Josephine

et al. 2020

Asian J Pharm Clin Res

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Objective: The current research work has been carried out with the aim to develop a transdermal gel formulation of fenoprofen (a nonsteroidal anti-inflammatory drug used to treat pain associated in arthritis) which would overcome the gastrointestinal-related problems associated with oral administration of the drug. The present study aims at formulating transdermal gels using different concentrations of Carbopol, hydroxypropyl methylcellulose (HPMC), sodium alginate, and guar gum. Methods: The formulated gels were subjected for various evaluation tests such as clarity, homogeneity, viscosity, drug content, pH, spreadability, and in vitro permeation studies. Drug–polymer interaction was studied by Fourier transmission infrared (FTIR) and differential scanning calorimetry (DSC). The in vitro permeation studies were performed in phosphate buffer 7.4 using Franz diffusion cell. Results: The FT-IR and DSC studies showed no chemical interaction between drug and polymers used. All the formulated gels showed acceptable physical properties with respect to clarity, homogeneity, viscosity, drug content, pH, and spreadability. Among all the gel formulations, Carbopol gels containing fenoprofen showed good drug release compared to HPMC, sodium alginate, and guar gum. Optimized formulation was further subjected to kinetic studies which showed Higuchi model of drug release. The same formulation showed significant anti-inflammatory and analgesic activity, tested in Wistar albino rats. No signs of erythema, edema, flushing, and papules were observed when skin irritation test was performed. Stability studies under accelerated condition showed satisfactory results for the optimized formulation. Conclusions: Thus, it was concluded from the results that the optimized formulation showed controlled and slow drug delivery. Animal studies were significant at p<0.05 and 0.001. The selected formulation was stable at various ambient temperatures.

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Design and Evaluation of Transdermal Films Containing Ketoprofen for the Treatment of Arthritis

Cited by 2 publications

References 1 publication

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Transdermal Delivery of an Effective Nonsteroidal Anti-Inflammatory Drugs for Pain Management in Arthritis

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