This study presents experimental and numerical investigations on seven one-way, reinforced concrete (RC) slabs with a new technique of slab weight reduction using polystyrene-embedded arched blocks (PEABs). All slabs had the same dimensions, steel reinforcement, and concrete compressive strength. One of these slabs was a solid slab, which was taken as a control slab, while the other six slabs were cast with PEABs. The main variables were the ratio of the length of the PEABs to the length of the slab (lp/L) and the ratio of the height of the PEABs to the total slab depth (hP/H). The minimum decrease in the ultimate load capacity was about 6% with a minimum reduction in the slab weight of 15%. In contrast, the maximum decrease in the ultimate load capacity was about 24% with a maximum reduction in the slab weight of 40%. Moreover, the mode of failure changed from flexure to shear failure, especially for those slabs with an lP/L ratio equal to one. The geometric and material non-linearity was adopted in the proposed finite element (FE) model to simulate the slabs with PEABs using Abaqus software. Good agreement was obtained between the developed FE and experimental results.