Design and fabrication of a microelectrode array for studying epileptiform discharges from rodents

Chatterjee, Suman; Joshi, Rathin K.; Sakorikar, Tushar; Behera, Bhagaban; Bhaskar, Nitu; Kv, Shabari Girishan; Jayachandra, Mahesh; Pandya, Hardik J.

doi:10.1007/s10544-023-00672-0

Cited by 1 publication

(1 citation statement)

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“…Lab on a chip integrated with an MN can be a useful mechanism for extracting as well as analysing the biomarkers in the interstitial fluids [3][4][5]. MNs are also finding applications in recording or stimulating neural activity [6,7], bio-signals [8], treatment of skin cancer [9], treatment of superficial skin tumors [10], stimulation of hair growth [11], treatment of retinal diseases [12,13], and collagen induction therapy for promoting the natural healing of skin [14]. Various methods have been developed to fabricate MNs of different shapes and sizes with materials such as polymers, ceramics and metals [15].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of microneedles using wire electric discharge machining and improving surface quality by electrochemical polishing

Sarkar,

Sidpara

2024

J. Micromech. Microeng.

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Microneedle (MN) arrays have many applications in biomedical engineering to deliver drugs transdermally or extract biomarkers from the interstitial fluid from the human skin. Several methods have been developed to fabricate different sizes and shapes of MN using polymers, ceramics and metals. However, most of these methods require expensive sophisticated machines and clean room facilities. So, it is difficult to fabricate microneedle arrays in large quantities at a reasonable cost. This study reports the fabrication of a high-quality stainless steel master pattern for an MN array using a wire-cut electric discharge machining (WEDM) process followed by electrochemical polishing (ECP). Different densities of a 5×5 array of microneedles with pyramidal shapes were fabricated by machining channels onto the workpiece surface in a crisscross pattern. A systematic experimental study was carried out with reference to the offset between the two consecutive channel faces and the depth of channels. The output parameters are MN height (MNH), MN base (MNBW) and tip width (MNTW). The average needle tip width, base width, and height of microneedles were found to be 55.3 µm, 680 µm, and 914.7 µm. Finally, the sharpness of the MN tips and the overall surface finish of the MN array were improved with ECP. The reductions in MNH, MNBW, and MNTW were reported to be -18.3 %, -9.7 %, and -95.4 %, respectively, with a final tip width of 2.55 ± 1.62 µm. The MNs' tip angle was reported to be 32.52° ± 1.56.

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