Transparent substrates with antifogging and antireflection ability are of extreme significance for optical devices, because they alleviate performance loss and maintenance costs. Here, we reported that a multifunctional film, with excellent mechanical properties, can be fabricated on the PMMA surface via the micro-transfer printing method. In particular, the synergistic effect of the inverted pyramid microstructure and SiO2 nanoparticles gives the film excellent antireflective, superhydrophilic and antifogging properties, and the silica sol firmly adheres to the PMMA substrate via the silane coupling agent, which exhibits an encouraging prospect of practical applications from lenses for personal and sports eyewear to transparent displays and sensors, etc.