Design and Facile Synthesis of New Bioactive C-glycosidic Semi-Natural Compounds

Abstract

T HE presented work aims to synthesize new bioactive molecules of wide spectrum biological activity. In this study, a new series of α,β unsaturated ketones having acylic sugar residue was synthesized along with their hydrazone analogues. Those new compounds were obtained via mild condensation reactions to avoid side products and were investigated by spectral analysis including IR, 1 HNMR (Proton Nuclear Magnetic Resonance), 13 CNMR (C-13 Nuclear Magnetic Resonance) and mass spectrometer. In addition, they were tested and evaluated as antimicrobial and antioxidant agents.Results revealed that compound 2d is the most promising antimicrobial agent among the tested compounds and it even exceeds the activity of the used standard antibacterial drug Ampicillin as well as it competes with the standard antifungal drug Amphotericin B. On the other hand, compound 3b shows potent antioxidant activity in comparison with the used standard drug Trolox. Structure-activity relationship is also discussed.The presented work aims to synthesize new bioactive molecules of wide spectrum biological activity. In this study, a new series of α,β unsaturated ketones having acylic sugar residue was synthesized along with their hydrazone analogues.Those new compounds were obtained via mild condensation reactions to avoid side products and were investigated by spectral analysis including IR, 1HNMR,13CNMR and mass spectrometer. In addition, they were tested and evaluated as antimicrobial and antioxidant agents.Results revealed that compound 2d is the most promising antimicrobial agent among the tested compounds and it even exceeds the activity of the used standard antibacterial drug Ampicillin as well as it competes with the standard antifungal drug Amphotericin B. On the other hand, compound 3b shows potent antioxidant activity in comparison with the used standard drug Trolox. Structure-activity relationship is also discussed.