Design and fluid-structure interaction analysis for a microfluidic T-junction with chemo-responsive hydrogel valves

Khanjani, Elham; Hajarian, Amin; Kargar-Estahbanaty, Arash; Arbabi, Nasser; Taheri, Ali; Baghani, Mostafa

doi:10.1007/s10483-020-2618-6

Cited by 11 publications

(5 citation statements)

References 37 publications

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“…In order to study the hydrogel pH variation over time, the average pH of the whole hydrogel structure is investigated. In most of the earlier studies, the stationary state is considered for the swelling of hydrogel (Arbabi et al, 2017;Khanjani et al, 2020;Mazaheri et al, 2020), and the FSI analysis was conducted where an unreal assumption takes into account. These studies consider that the pH value of the hydrogel changes similarly in the whole hydrogel structure, while in reality, the distance of each point to the hydrogel boundary is one of the main points in determining the exact value of the hydrogen concentration.…”

Section: Resultsmentioning

confidence: 99%

“…In other words, not only the resultant fluid pressure is applied to the solid structure, but also regarding the deformation of the solid structure, the fluid domain is updated. Most of the previous FSI analyses have been carried out in the equilibrium states (Amiri and Mazaheri, 2020;Arbabi et al, 2017;Khanjani et al, 2020;Mazaheri et al, 2018;Zhang et al, 2012). However, the transient swelling process of hydrogels cannot be observed in such studies.…”

Section: Introductionmentioning

confidence: 99%

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PH-sensitive hydrogel-based valves: A transient fully-coupled fluid-solid interaction study

Niroumandi

Shojaeifard

Baghani

2021

Journal of Intelligent Material Systems and Structures

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pH-sensitive hydrogels are promising materials to be employed in microfluidic devices, especially microvalves. In this paper, a theory of transient swelling of pH-sensitive micro-valve is presented. A transient constitutive model that captures electrical, chemical, and mechanical fields is considered to model the swelling phenomenon. The diffusion of ions into the hydrogel, the electromigration, and convection are described by implementing the Nernst-Planck equation. Assuming Gent model, hydrogel is considered as a compressible hyperelastic material and osmotic pressure is assumed as an external loading. Due to benefits of in-plane valves, a design of the micro-valve is studied. Design simplicity and great sealing are vital factors which can be considered as an advantage of this valve for fabrication. This design and modeling approach has not been used for pH-sensitive hydrogels in earlier works. Thus, we have studied the transient swelling of pH-sensitive hydrogel microvalve, when effects of fluid-structure-interaction are examined on valve performance. It is noted that in most previous studies, equilibrium conditions have been assumed. While considering transient fully-coupled fluid-structure-interaction is necessary to capture a more realistic modeling. The results illustrate that the microvalve blocks the channel much earlier than reaching the equilibrium-state, which implies importance of the transient behavior of hydrogels.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PH-sensitive hydrogel-based valves: A transient fully-coupled fluid-solid interaction study

Niroumandi

Shojaeifard

Baghani

2021

Journal of Intelligent Material Systems and Structures

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“…These phenomena are characterized by the interaction of fluid between the deformable, and movable T-microcantilevers and the surrounding fluid flow. Fluid flow in the microchannel and T-microcantilever was placed at the centre of the channel when fluid encountered the microcantilever strain and stress exerted on the T-microcantilever surface [26]. The T-microcantilever is deformed due to applied pressure, and the deformation of a microcantilever can be large or small depending on the fluid velocity, relative pressure, and material properties of Tmicrocantilever.…”

Section: Principle Of Fluid-structure Interactionmentioning

confidence: 99%

Optimization of Newtonian fluid pressure in microcantilever integrated flexible microfluidic channel for healthcare application

Saxena,

Kumar,

Mishra

et al. 2024

Biomed. Phys. Eng. Express

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The demand for microfluidic pressure sensors is ever-increasing in various industries due to their crucial role in controlling fluid pressure within microchannels. While syringe pump setups have been traditionally used to regulate fluid pressure in microfluidic devices, they often result in larger setups that increase the cost of the device. To address this challenge and miniaturize the syringe pump setup, the researcher introduced integrated T-microcantilever-based microfluidic devices. In these devices, microcantilevers are incorporated, and their deflections correlate with the microchannel's pressure. When the relative pressure of fluid (plasma) changes, the T-microcantilever deflects, and the extent of this deflection provides information on fluid pressure within the microchannel. In this work, finite element method (FEM) based simulation was carried out to investigate the role of material, and geometric parameters of the cantilever, and the fluid viscosity on the pressure sensing capability of the T-microcantilever integrated microfluidic channel. The T-microcantilever achieves a maximum deflection of 127 µm at a 5000 µm/s velocity for Young’s modulus(E) of 360 kPa of PDMS by employing a hinged structure. On the other hand, a minimum deflection of 4.05 x 10-5 µm was attained at 5000 µm/s for Young’s modulus of 1 TPa for silicon. The maximum deflected angle of the T-cantilever is 20.46o for a 360 kPa Young’s modulus while the minimum deflection angle of the T-cantilever is measured at 13.77o for 900 KPa at a fluid velocity of 5000 µm/s. The T-cantilever functions as a built-in microchannel that gauges the fluid pressure within the microchannel. The peak pressure, set at 8.86 Pa on the surface of the cantilever leads to a maximum deflection of 0.096 µm (approximately 1 µm) in the T-cantilever at a 1:1 velocity ratio. An optimized microfluidic device embedded with microchannels can optimize fluid pressure in a microchannel support cell separation.

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“…In this study, the hydrogel is used to develop soft robotic switches, resulting in a novel functional oscillator. Valve / [13,14] Pressure valve HEMA/AA [15] Check valve PEGDA [16] Flow sorter HEMA/AA HEMA/DMAEMA [17] Bath solution + -…”

Section: Introductionmentioning

confidence: 99%

Electroresponsive Hydrogel-Based Switching Components for Soft, Bioelectrical, and Fluidic Circuits

Philamore

2022

Advances in Polymer Technology

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The development of various soft components for fluid circuits is conducive to the further development of soft robots. The electroresponsive hydrogel is applied to build a functional oscillator in the study conducted. Based on the multiphasic mixture model, the deformation of the hydrogel under external electric fields is analyzed through COMSOL Multiphysics simulator. Owing to the characteristics of the hydrogel that it will deform in response to electric field, the hydrogel is employed to control fluidic circuits, resulting in a novel controllable functional soft oscillator.

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Design and fluid-structure interaction analysis for a microfluidic T-junction with chemo-responsive hydrogel valves

Cited by 11 publications

References 37 publications

PH-sensitive hydrogel-based valves: A transient fully-coupled fluid-solid interaction study

PH-sensitive hydrogel-based valves: A transient fully-coupled fluid-solid interaction study

Optimization of Newtonian fluid pressure in microcantilever integrated flexible microfluidic channel for healthcare application

Electroresponsive Hydrogel-Based Switching Components for Soft, Bioelectrical, and Fluidic Circuits

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