Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether)

Abstract

This is the first report where PFPAE aromatic conjugates and perfluoro(polyethylene glycol dimethyl ether) are combined and formulated as nanoemulsions with droplet size below 100 nm. A perfluoropolyalkylether (PFPAE) aromatic conjugate, 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene, was used as fluorophilic-hydrophilic diblock (FLD) aimed at stabilizing perfluoro(polyethylene glycol dimethyl ether) nanoemulsions. Its effects on colloidal behaviors in triphasic (organic/fluorous/aqueous) nanoemulsions were studied. The addition of FLD construct to fluorous phase led to decrease in PFPAE nanoemulsion droplet size to as low as 85 nm. Prepared nanoemulsions showed high colloidal stability. Our results suggest that these materials represent viable novel approach to fluorous colloid systems design with potential for biomedical and synthetic applications.

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal 19F MRI Agents

“…A complete list of peptides used in this study can be found in Figure S1 B) Disordered peptide design showing 19 F sources alternating with positive charge causing a random-coil through electrostatic repulsion. C) Select fluorinated molecules used for 19 F MRI: i) Perfluoro-15-crown-5 ether [6] ii) Perfluoro(polyethylene glycol) methyl ether [13] and iii) PERFECTA. [14] …”

“…B) Disordered peptide design showing 19 F sources alternating with positive charge. C) Select fluorinated molecules used for 19 F MRI: i) Perfluoro‐15‐crown‐5 ether ii) Perfluoro(polyethylene glycol) methyl ether and iii) PERFECTA …”

Experimental Study of Nanofluids Applied in EOR Processes

“…The former are thermodynamically unstable systems and usually require energy input for their formation while the latter are thermodynamically stable and form spontaneously. The main advantage of nanoemulsions over microemulsions is the use of moderate to low surfactant concentration, considering that microemulsions require large amounts of surface active matter [10][11][12][13][14][15][16][17].…”

Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarbon based artificial oxygen carriers

“…Therefore, creative and inventive solutions to development of PFC AOCs which provide rigorous understanding of colloidal attributes are in demand 18 . As an alternative to the above strategies, our group reported PFC-NEs with high colloidal stability by introducing hydrocarbon oil to the internal phase to form triphasic nanoemulsions, as opposed to biphasic, PFC in water systems [31][32][33][34][35][36] . These PFC-NEs achieved shelf-life beyond 360 days and were stable when mixed with biological media (no change after 14 days exposure).…”