Design and formulation of polymeric nanosponge tablets with enhanced solubility for combination therapy

Moin, Afrasim; Roohi, N. K. Famna; Rizvi, Syed Mohd Danish; Ashraf, Syed Amir; Siddiqui, Arif Jamal; Patel, Mitesh; Ahmed, Snober; Gowda, D. V.; Adnan, Mohd

doi:10.1039/d0ra06611g

Cited by 39 publications

(29 citation statements)

References 30 publications

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“…observed, as NSs show a homogeneous phase, with the absence of microcrystals of the drugs, confirming the inclusion of the guest molecules in the NSs cavities and excluding the possibility of co-precipitation of the individual phases [16,19,38,48].…”

Section: Sem Analyses Of the Icsmentioning

confidence: 59%

“…The images reveal the highly porous morphology of the NSs, whereas MPH and CYT show rectangular crystals and rods, respectively. After drug loading, changes in the surface of the samples were observed, as NSs show a homogeneous phase, with the absence of microcrystals of the drugs, confirming the inclusion of the guest molecules in the NSs cavities and excluding the possibility of co-precipitation of the individual phases [ 16 , 19 , 38 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…As such, β-CD has been used to form nano-porous polymers [ 15 ]. The rising popularity of NSs as the material of choice over native CD is mainly due to their higher entrapment capacities, control over particle size and their ability to be regenerated and reutilized [ 16 , 17 , 18 , 19 ]. NSs can also improve the physicochemical properties of the guest molecules, such as solubility and stability, and absorb liquids into their nano-porous structure to convert liquid materials into a solid form [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…NSs have been proven to be safe, non-toxic, biodegradable, and of low cost [ 22 , 23 , 24 ]. As such, NSs have gained attention in targeted drug delivery research aimed at improving the efficacy of chemotherapies and reducing the adverse effects related to the drugs [ 16 , 17 , 18 , 20 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Salazar

Yutronic

Kogan

et al. 2021

IJMS

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This article describes the synthesis and characterization of β-cyclodextrin-based nano-sponges (NS) inclusion compounds (IC) with the anti-tumor drugs melphalan (MPH) and cytoxan (CYT), and the addition of gold nanoparticles (AuNPs) onto both systems, for the potential release of the drugs by means of laser irradiation. The NS-MPH and NS-CYT inclusion compounds were characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), energy dispersive spectroscopy (EDS), thermogravimetric analysis (TGA), UV–Vis, and proton nuclear magnetic resonance (1H-NMR). Thus, the inclusion of MPH and CYT inside the cavities of NSs was confirmed. The association of AuNPs with the ICs was confirmed by SEM, EDS, TEM, and UV–Vis. Drug release studies using NSs synthesized with different molar ratios of β-cyclodextrin and diphenylcarbonate (1:4 and 1:8) demonstrated that the ability of NSs to entrap and release the drug molecules depends on the crosslinking between the cyclodextrin monomers. Finally, irradiation assays using a continuous laser of 532 nm showed that photothermal drug release of both MPH and CYT from the cavities of NSs via plasmonic heating of AuNPs is possible.

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Section: Sem Analyses Of the Icsmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Salazar

Yutronic

Kogan

et al. 2021

IJMS

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show abstract

“…Cyclodextrin-based nanosponges have been designed in the last years to increase the dissolution rate, the solubility and stability of drugs, or to prolong the release time, and also applied in semisolid formulations for skin delivery (Ansari et al 2011 ; Shende et al 2013 ; Conte et al 2014 ). Recently, experimental design has been used to formulate tablets using polymeric nanosponges for a combination therapy of three anti-inflammatory drugs (Moin et al 2020 ).…”

Section: Applications In the Food And Pharmaceutical Areasmentioning

confidence: 99%

History of cyclodextrin-based polymers in food and pharmacy: a review

Petitjean

García-Zubiri²,

Isasi

2021

Environ Chem Lett

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Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Gowda,

Ahmed,

Almoyad

et al. 2023

Adv Funct Materials

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Nanosponges are unique sponge‐like carrier systems with numerous cavities and a mesh‐like network throughout their surface. They are categorized into three types based on the material of construction, i.e., polymer‐, inorganic‐, and bio‐derived material‐based nanosponges. Unlike conventional nanoparticles, nanosponges bear countless interconnected voids and mesh‐like network that enables maximum drug, imaging probe, or photosensitizer loading via absorption, encapsulation, conjugation, or complexion. The voids can be further sealed using suitable lipids or polymers to avoid leakage of drugs at the non‐target site, protect therapeutics from biological conditions, and control the release of therapeutics for a prolonged period. Recently, nanosponges have grasped the attention of researchers in the area of cancer by overcoming the drawbacks associated with the conventional delivery of immunotherapeutic, targeted therapeutic, and chemotherapeutic agents. Interestingly, several reports have also witnessed their potential in cancer theranostics. Owing to this supremacy, nanosponges could be an apt platform for cancer therapy and diagnosis. The current review discusses the general aspects, types, and preparation methods of nanosponges. In addition, the ambit of nanosponges in treating different types of cancer is meticulously discussed, along with detailed descriptions of their corresponding patents. Furthermore, the role of nanosponges in phototherapy and cancer theranostics are selectively canvassed.

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Design and formulation of polymeric nanosponge tablets with enhanced solubility for combination therapy

Abstract: Polymeric nanosponges as potential carriers for successful combination therapy of poorly soluble drugs (paracetamol, aceclofenac, caffeine).

Cited by 39 publications

References 30 publications

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

History of cyclodextrin-based polymers in food and pharmacy: a review

Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

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