The flow field induced by multirotor drones is of high interest for atmospheric research, as it locally influences the atmosphere and therefore may have an impact on the sensors installed for atmospheric measurements. Further, on-board vibrations can cause significant interference with the measurement equipment. To investigate the near flow field, an approach combining measurements of pressure and temperature distribution in-flight and in a laboratory setup together with numerical simulations was applied. Existing high-frequency measurement equipment was piggybacked during the initial flight tests with a newly developed 25 kg quadcopter system in a low-cost early-stage-error approach to obtain initial data and experience. During the flights, high resolution sensors for measuring pressure, temperature, acceleration, and deformation were applied with different setups at different locations below one of the rotor planes, respectively, at one rotor arm, to determine the multicopter’s influence on pressure and temperature measurements, to investigate rotor arm deformations, and to obtain data to compare with numerical simulations of this rotor setup. An external Schlieren-type measurement technique was tested to visualise the rotor vortices. The applied measurement techniques proved to be suitable for acquiring the state of the rotor-induced flow, but with some limitations. The comparison of measurements and simulations showed basic agreement and allowed for the identification of necessary adaptations for subsequent studies. The interaction of the rotor wakes with the rotor arms could be identified as the main source of the measured structural vibrations. The need for necessary improvements in the measurement setup, flight operation, and simulation setup is presented in detail.