Abstract. Many important phenomena in science and engineering, including our motivating problem of microstructural blood flow, can be modeled as flows with dynamic interfaces. The major challenge faced in simulating such flows is resolving the interfacial motion. Lagrangian methods are ideally suited for such problems, since interfaces are naturally represented and propagated. However, the material description of motion results in dynamic meshes, which become hopelessly distorted unless they are regularly regenerated. Lagrangian methods are particularly challenging on parallel computers, because scalable dynamic mesh methods remain elusive. Here, we present a parallel dynamic mesh Lagrangian method for flows with dynamic interfaces. We take an aggressive approach to dynamic meshing by triangulating the propagating grid points at every timestep using a scalable parallel Delaunay algorithm. Contrary to conventional wisdom, we show that the costs of the geometric components (triangulation, coarsening, refinement, and partitioning) can be made small relative to the flow solver.1. Motivation. Flows with dynamic interfaces arise in many fluid-solid and fluid-fluid interaction problems, and are among the most difficult computational problems in continuum mechanics. Examples abound in the aerospace, automotive, biomedical, chemical, marine, materials, and wind engineering sciences. These include large-amplitude vibrations of such flexible aerodynamic components as high aspect ratio wings and blades; flows of mixtures and slurries; wind-induced deformation of towers, antennas, and lightweight bridges; hydrodynamic flows around offshore structures; interaction of biofluids with elastic vessels; and materials phase transition problems.One of our target problems is modeling the flow of blood at the microstructural level. Blood is a mixture of deformable cellular bodies (primarily red blood cells) suspended in an essentially Newtonian fluid (plasma). The cells themselves are composed of a fluid gel (hemoglobin) contained within a solid membrane. The flow of the fluid-solid mixture is illustrated in Figure 1.1a, which depicts a snapshot of blood flow through a 12m arteriole. Because of the computational difficulties of resolving numerous dynamically deforming cellular interfaces, as illustrated in Figure 1.1b, no one to date has simulated realistic blood flows at the microstructural level. Yet such simulations are necessary in order to gain a better understanding of blood damage-which is central to improved artificial organ design-and for the development of more rational macroscopic blood models.We are specifically interested in simulating the flow of blood in artificial heart assist devices, such as the axial flow blood pump being developed at the University of Pittsburgh Medical Center [16]. Such pumps have regions in which the length scales of interest are of the order of tens of cell diameters, for example in bearing journals and near blade tips. Significant blood damage can occur in these "hot spots." Here, macroscopic ...