Starting from the necessity and principles of database design, this article explores the optimization issues. Firstly, analyze the necessity of database design, elaborating on effective management, maintainability, resource utilization, and running speed; Then, a series of issues in database management were discussed, such as user management, data object design specifications, and overall design ideas; Finally, the optimization issues such as normalization rules, inter table redundancy handling, query optimization, indexing, and transactions were elaborated in detail. In the software development lifecycle, database design is indispensable. Its role is not only to ensure the safety and reliability of data, but also to ensure the overall stability and speed of the system. Strengthening the rationality and optimization of design is the key to improving software quality.