Design and In Vivo Evaluation of a Patch System Based on Thiolated Polymers

Hoyer, Herbert; Greindl, Melanie; Bernkop‐Schnürch, Andreas

doi:10.1002/jps.21480

Cited by 9 publications

(1 citation statement)

References 28 publications

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“…Bernkop-Schnürch and coworkers (Bernkop-Schnürch, 2005;Hoyer et al, 2009) developed the intestinal patches for oral delivery of insulin. It was observed that the patches were able to release around 75% of loaded insulin in 6 hours.…”

Section: Intestinal Patchesmentioning

confidence: 99%

Oral Drug Delivery Technologies—A Decade of Developments

Kaur

Arora

Kumar

2019

J Pharmacol Exp Ther

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Advanced drug delivery technologies, in general, enable drug reformulation and administration routes, together contributing to life-cycle management and allowing the innovator to maintain the product monopoly. Over the years, there has been a steady shift from mere life-cycle management to drug repurposingapplying delivery technologies to tackle solubility and permeability issues in early stages or safety and efficacy issues in the late stages of drug discovery processes. While the drug and the disease in question primarily drive the choice of route of administration, the oral route, for its compliance and safety attributes, is the most preferred route, particularly when it comes to chronic conditions, including pain, which is not considered a disease but a symptom of a primary cause. Therefore, the attempt of this review is to take a stock of the advances in oral delivery technologies that are applicable for injectable to oral transformation, improve risk-benefit profiles of existing orals, and apply them in the early discovery program to minimize the drug attrition rates.

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Section: Intestinal Patchesmentioning

confidence: 99%