Design and material evaluation for a novel lumbar disc replacement implanted via unilateral transforaminal approach

Alvarez, Alba Gonzalez; Dearn, Karl D.; Shepherd, Duncan E.T.

doi:10.1016/j.jmbbm.2018.12.011

Cited by 10 publications

(10 citation statements)

References 25 publications

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“…Furthermore, the annulus needs to be kept under appropriate tension, and the endplates must not support any of its surfaces at a higher load than it can tolerate [ 28 ]. In this respect, polycarbonate urethane is a polymer group with high resistance to pressure and good tensile strength [ 29 ], besides being biocompatible [ 30 ]. Bionate ® II 80A (DSM Corporate, Heerlen, Netherlands) stiffness at 1 mm displacement is 448.48 N/mm, and plastic deformation is 1.1 ± 0.2% [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this respect, polycarbonate urethane is a polymer group with high resistance to pressure and good tensile strength [ 29 ], besides being biocompatible [ 30 ]. Bionate ® II 80A (DSM Corporate, Heerlen, Netherlands) stiffness at 1 mm displacement is 448.48 N/mm, and plastic deformation is 1.1 ± 0.2% [ 29 ]. Other materials have been tested, like cellulose [ 31 ], silicones [ 32 ], hydrogels [ 33 ], polymers [ 34 ], and alginates [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Bionate® nucleus disc replacement: bench testing comparing two different designs

Vanaclocha¹,

Vanaclocha

Atienza

et al. 2023

J Orthop Traumatol

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Background Intervertebral disc nucleus degeneration initiates a degenerative cascade and can induce chronic low back pain. Nucleus replacement aims to replace the nucleus while the annulus is still intact. Over time, several designs have been introduced, but the definitive solution continues to be elusive. Therefore, we aimed to create a new nucleus replacement that replicates intact intervertebral disc biomechanics, and thus has the potential for clinical applications. Materials and methods Two implants with an outer ring and one (D2) with an additional midline strut were compared. Static and fatigue tests were performed with an INSTRON 8874 following the American Society for Testing and Materials F2267-04, F2346-05, 2077-03, D2990-01, and WK4863. Implant stiffness was analyzed at 0–300 N, 500–2000 N, and 2000–6000 N and implant compression at 300 N, 1000 N, 2000 N, and 6000 N. Wear tests were performed following ISO 18192-1:2008 and 18192-2:2010. GNU Octave software was used to calculate movement angles and parameters. The statistical analysis package R was used with the Deducer user interface. Statistically significant differences between the two designs were analyzed with ANOVA, followed by a post hoc analysis. Results D1 had better behavior in unconfined compression tests, while D2 showed a “jump.” D2 deformed 1 mm more than D1. Sterilized implants were more rigid and deformed less. Both designs showed similar behavior under confined compression and when adding shear. A silicone annulus minimized differences between the designs. Wear under compression fatigue was negligible for D1 but permanent for D2. D1 suffered permanent height deformation but kept its width. D2 suffered less height loss than D1 but underwent a permanent width deformation. Both designs showed excellent responses to compression fatigue with no breaks, cracks, or delamination. At 10 million cycles, D2 showed 3-times higher wear than D1. D1 had better and more homogeneous behavior, and its wear was relatively low. It showed good mechanical endurance under dynamic loading conditions, with excellent response to axial compression fatigue loading without functional failure after long-term testing. Conclusion D1 performed better than D2. Further studies in cadaveric specimens, and eventually in a clinical setting, are recommended. Level of evidence 2c.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bionate® nucleus disc replacement: bench testing comparing two different designs

Vanaclocha¹,

Vanaclocha

Atienza

et al. 2023

J Orthop Traumatol

View full text Add to dashboard Cite

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“…Polyurethane exhibit special absorbed compressional energy performance when subjected to mechanical impact and compression, providing them with certain advantages in mimicking the cushioning and shock absorption functions of the normal intervertebral disc. Gonzalez et al [ 25 ] also reported that elastomeric lumbar disc replacement with PU could excellently mimic the axial compliance of the spine.…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties of an elastically deformable cervical spine implant

Abudouaini

Meng

et al. 2023

J Orthop Surg Res

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Anterior cervical surgery is widely accepted and time-tested surgical procedure for treating cervical radiculopathy and myelopathy. However, there is concern about the high adjacent segment degeneration rate and implant subsidence after the surgery using the traditional polyetheretherketone cage. Thus, we creatively designed a polyurethane cervical implant that can continuous load-sharing through elastic deformation and decrease postoperative stress concentration at adjacent segments. In this study, the design rationality and safety of this novel implant was evaluated based on several mechanical parameters including compression test, creeping test, push-out test and subsidence test. The results showed that the novel cervical implant remained intact under the compressive axial load of 8000 N and continues to maintained the elastic deformation phase. The minimum push-out load of the implant was 181.17 N, which was significantly higher than the maximum compressive shear load of 20 N experienced by a normal human cervical intervertebral disc. Besides, the creep recovery behaviour of the implant closely resembled what has been reported for natural intervertebral discs and clinically applied cervical devices in literature. Under the load of simulating daily activities of the cervical spine, the implant longitudinal displacement was only 0.54 mm. In conclusion, this study showed that the current design of the elastically deformable implant was reasonable and stable to fulfil the mechanical requirements of a cervical prosthesis under physiological loads. After a more comprehensive understanding of bone formation and stress distribution after implantation, this cervical implant is promising to be applied to certain patients in clinical practice.

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“…For control discs (no fiber reinforcement), 11 ml of 10:1 elastomer base: curing agent polydimethylsiloxane (PDMS) (Sylgard™ 184 Silicone, Dow Corning, Midland, MI, USA) was poured into the mold and cured in at 65 °C over for 24 h to reach a final disc height of 7 mm. PDMS was used as a model elastomer due to its low cost, mechanical robustness, ease of use, and lengthy history in biomedical applications, particularly as a component in lumbar disc replacements [ 35 , 36 ]. After removal from the mold, the PDMS discs were die-cut using a custom cut mold based to fit between the L4 and L5 vertebrae ( Fig.…”

Section: Methodsmentioning

confidence: 99%

Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering

McCarthy

Avegnon

Holubeck

et al. 2021

Materials Today Bio

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Electrostatic flocking is a textile technology that employs a Coulombic driving force to launch short fibers from a charging source towards an adhesive-covered substrate, resulting in a dense array of aligned fibers perpendicular to the substrate. However, electrostatic flocking of insulative polymeric fibers remains a challenge due to their insufficient charge accumulation. We report a facile method to flock electrostatically insulative poly(ε-caprolactone) (PCL) microfibers (MFs) and electrospun PCL nanofiber yarns (NFYs) by incorporating NaCl during pre-flock processing. Both MF and NFY were evaluated for flock functionality, mechanical properties, and biological responses. To demonstrate this platform's diverse applications, standalone flocked NFY and MF scaffolds were synthesized and evaluated as scaffold for cell growth. Employing the same methodology, scaffolds made from poly(glycolide-co- l -lactide) (PGLA) (90:10) MFs were evaluated for their wound healing capacity in a diabetic mouse model. Further, a flock-reinforced polydimethylsiloxane (PDMS) disc was fabricated to create an anisotropic artificial vertebral disc (AVD) replacement potentially used as a treatment for lumbar degenerative disc disease. Overall, a salt-based flocking method is described with MFs and NFYs, with wound healing and AVD repair applications presented.

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Design and material evaluation for a novel lumbar disc replacement implanted via unilateral transforaminal approach

Cited by 10 publications

References 25 publications

Bionate® nucleus disc replacement: bench testing comparing two different designs

Bionate® nucleus disc replacement: bench testing comparing two different designs

Mechanical properties of an elastically deformable cervical spine implant

Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering

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