“…However, the spherical crystallization mentioned in the abovementioned studies mainly uses batch crystallization. Slow heat transfer, backmixing, dispersed residence time, and strong agitation in the vessel are the inherent deficiencies of this route, which may contribute to the nonuniform growth and wider crystal size distribution. , This can have a negative impact on the downstream operations of crystalline products and the final product quality. , As a result, there remains a need to propose an improved method to compensate for the shortcomings of the current spherical crystallization.…”