Parque das Conchas (BC-10) is a deepwater development offshore Brazil. A novel Caisson / Electrical Submersible Pump (ESP) subsea separator (gas/liquid) and pumping system to enhance production and maximize recovery has been utilized as part of the development of two of the fields (Ostra and Abalone). A third field, Argonauta B-West utilizes multiphase boosting with a modified Caisson/ESP (C-ESP) system to operate with a single, non-separated multiphase outlet. These novel designs have significantly impacted system and flow assurance engineering such as separator level control, hydrate mitigation, system operability, and chemical injection. The fields have been successfully started up with production through the subsea processing system since late 2009. This paper outlines the performance of the subsea processing and production system from the perspective of flow assurance, and presents comparisons of the actual operating performance to design expectations. Learnings from key factors that strongly impact the production system operability and operational strategies are discussed, including the achieved separation efficiency of the caisson, the impact of defoamer performance on caisson operation and the importance of the hot oil circulation system.