Design and optimization of a multistage continuous cooling mixed suspension, mixed product removal crystallizer

Power, G.; Hou, Guangyang; Kamaraju, Vamsi Krishna; Morris, Gary; Zhao, Yan; Glennon, Brian

doi:10.1016/j.ces.2015.02.014

Cited by 82 publications

(127 citation statements)

References 24 publications

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“…13,[32][33][34] In addition, there are several recent reports about the optimization of the multistage MSMPR crystallizer. 8,9,[35][36][37] However, no general analysis of the effects of various crystallization kinetic parameters on the effective operating strategy for the crystallization system has been carried out. This kind of analysis is important because it can be a guideline for the appropriate design and operation of a continuous multistage MSMPR crystallization process when the crystallization kinetic data are available.…”

Section: Introductionmentioning

confidence: 99%

Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

Park

Kim

Yang

2016

Ind. Eng. Chem. Res.

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Continuous multistage MSMPR crystallization processes are useful for the large scale production of particulate systems. However, the design of operating strategies to meet specific objectives and materials has not been entirely investigated. In this work, the effect of important crystallization kinetic parameters on the optimal operating strategy was examined. The important parameters are the kinetic constants of the primary and secondary nucleation rates, the orders of the nucleation and growth rates, and the number of crystallizer stages. The analyses revealed that a drastic cooling strategy in the primary nucleation dominant region and linear cooling in the secondary nucleation dominant region are best for producing large particle sizes. A stage number of around three is effective in both regions.These results can be utilized to roughly determine the operating strategy for a process, if the crystallization kinetic parameters are already roughly known.

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Section: Introductionmentioning

confidence: 99%

Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

Park

Kim

Yang

2016

Ind. Eng. Chem. Res.

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“…The duration of each experiment was approximately 4.6 h (inclusive of the start-up period). The process was operated for approximately 18 RTs from the point of nucleation detection in the MSMPR.…”

Section: Continuous Crystallization Studiesmentioning

confidence: 99%

“…16,17 The breaking off of crusts from the crystallizer walls can then lead to line blockages as well as particle settling and classification due to the difference in flow velocities in the agitated crystallizer or in transfer lines. To overcome these challenges in MSMPR operation, researchers have used different operating strategies to varying degrees of success, for example, intermittent withdrawal 9,18,19 and, more recently, periodic flow operation. 20 In this study, a two-pronged approach was taken to alleviate fouling and encrustation in MSMPR.…”

Section: Introductionmentioning

confidence: 99%

Monitoring Continuous Crystallization of Paracetamol in the Presence of an Additive Using an Integrated PAT Array and Multivariate Methods

Powell

Saleemi²,

Rielly

et al. 2016

Org. Process Res. Dev.

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In this study, an automated intelligent decision support (IDS) framework was applied to monitor the continuous crystallization of form I paracetamol (PCM) and determine steady-state operation. A modified single-stage mixed suspension mixed product removal (MSMPR) crystallizer was used to investigate methods to minimize early onset of fouling and encrustation by carrying out crystallizations in the presence and absence of hydroxyl propyl methyl cellulose (HPMC) additive. The effectiveness of HPMC toward controlling the crystallization process and alleviating fouling and encrustation for prolonged operation of the MSMPR was investigated over a range of concentrations. HPMC was found to suppress nucleation and growth, thereby controlling the crystallization and alleviating fouling and encrustation over extended operating periods. HPMC also affected the product crystal morphology, leading to predominantly tabular shaped crystals. Steady state in the MSMPR was characterized using the IDS, which consisted of an integrated and ancillary array of process analytical technologies (PAT), including the application of Raman spectroscopy with multivariate calibration for solution phase concentration measurement.

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“…В реальных условиях, как правило, из-вестны температура кристаллизуемого сиропа, его количество, процентное содержание молочного сахара и сухих веществ в нем, Конечная темпера-тура и содержание молочного сахара в конечном растворе задаются [4][5][6][7].…”

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“…Данное время обусловлено интенсифика-цией процесса изогидрической кристаллизации кристаллов лактозы при использовании низко-частотных гармонических колебаний [7,12] Находим расход воды: Справедливость составления материаль-ного и теплового баланса и определения расхода охлаждающей воды проверяется следу-ющим расчетом.…”

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Approximate engineering calculation of chill molds for milk sugar in isohydric conditions

Полянский¹,

Калашников²,

Муравьев³

2018

Vestn. Voronež. gos. univ. inž. tehnol.

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Design and optimization of a multistage continuous cooling mixed suspension, mixed product removal crystallizer

Cited by 82 publications

References 24 publications

Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

Monitoring Continuous Crystallization of Paracetamol in the Presence of an Additive Using an Integrated PAT Array and Multivariate Methods

Approximate engineering calculation of chill molds for milk sugar in isohydric conditions

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